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Genetic Study of Familial Factors in Patients With Colon Cancer

2014-07-23 21:52:29 | BioPortfolio

Summary

RATIONALE: Genetic studies may help in understanding the genetic processes involved in the development of some types of cancer.

PURPOSE: Clinical trial to study the cancer-related genes in patients who have colon cancer or adenomatous polyps.

Description

OBJECTIVES:

- Identify human colon neoplasia susceptibility genes in patients with colon cancer or adenomatous polyps.

- Correlate the inheritance of novel susceptibility alleles for adenomatous polyposis of the colon with colon neoplasia in these patients.

- Correlate colon neoplasia susceptibility with the presence of COX-2, sPLA2, and DNMT genes in these patients.

- Identify a novel gene that governs increased susceptibility to colon adenoma and cancer in the genome of these patients.

OUTLINE: This is a multicenter study.

Patients donate blood samples for analysis of colorectal susceptibility genes. Patients also complete a questionnaire regarding family cancer history.

A certificate of confidentiality protecting the identity of research participants in this project has been issued by the National Cancer Institute.

Participants do not receive the results of the genetic testing, and the results do not influence the type or duration of treatment.

PROJECTED ACCRUAL: A total of 600 patients (300 sibling pairs) will be accrued for this study.

Study Design

N/A

Conditions

Colorectal Cancer

Intervention

cytogenetic analysis, gene mapping, microarray analysis

Location

Wayne Memorial Hospital, Incorporated
Goldsboro
North Carolina
United States
27534

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:52:29-0400

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