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Genetic Study of Patients With Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Myelodysplastic Syndromes, or Multiple Myeloma

2014-08-27 03:55:41 | BioPortfolio

Summary

RATIONALE: Cytogenetic tests may help predict how cancer will respond to treatment and allow doctors to plan more effective therapy.

PURPOSE: This diagnostic trial is studying genetic differences in patients with treated and untreated acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, or multiple myeloma.

Description

OBJECTIVES:

- Determine the incidence of chromosomal abnormalities in patients with acute myeloid leukemia, acute lymphoblastic leukemia, myelodysplastic syndromes, or multiple myeloma.

- Correlate specific chromosomal abnormalities with clinical and laboratory parameters in these patients.

- Correlate specific karyotype groups with treatment response rates, response duration, survival, and cure in patients treated with various induction and post-induction regimens.

- Correlate specific karyotype groups with multidrug resistance data in these patients.

- Identify new chromosome abnormalities important in leukemogenesis.

- Correlate specific karyotype groups with epidemiological data (toxic exposure and family history) in these patients.

- Determine karyotype changes at relapse and the influence of the type of change (or no change) in karyotype at relapse in subsequent clinical courses in these patients.

- Correlate specific karyotype groups with selected molecular abnormalities as studied in CALGB leukemia protocols.

OUTLINE: This is a multicenter study.

Patients undergo collection of bone marrow and blood specimens for cytogenetic analysis at diagnosis, complete remission, and relapse. Specimens are karyotyped and examined for chromosomal abnormalities.

PROJECTED ACCRUAL: Approximately 6,400 patients will be accrued for this study.

Study Design

Primary Purpose: Diagnostic

Conditions

Leukemia

Intervention

chromosomal translocation analysis, cytogenetic analysis

Location

UAB Comprehensive Cancer Center
Birmingham
Alabama
United States
35294

Status

Recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:41-0400

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Medical and Biotech [MESH] Definitions

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A method of chemical analysis based on the detection of characteristic radionuclides following a nuclear bombardment. It is also known as radioactivity analysis. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

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Meta-analysis of randomized trials in which estimates of comparative treatment effects are visualized and interpreted from a network of interventions that may or may not have been evaluated directly against each other. Common considerations in network meta-analysis include conceptual and statistical heterogeneity and incoherence.

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