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Erlotinib in Treating Patients With Advanced Esophageal Cancer or Stomach Cancer

2014-08-27 03:55:47 | BioPortfolio

Summary

RATIONALE: Erlotinib may stop the growth of cancer by blocking the enzymes necessary for tumor cell growth.

PURPOSE: This phase II trial is studying erlotinib to see how well it works in treating patients with advanced esophageal cancer or stomach cancer.

Description

OBJECTIVES:

- Determine the objective response rate in patients with advanced carcinoma of the esophagus or gastroesophageal junction treated with erlotinib.

- Determine the overall survival of patients treated with this drug.

- Determine the degree of dysphagia relief in patients treated with this drug.

- Determine the toxicity and tolerability of this drug in these patients.

- Correlate epidermal growth factor receptor (EGFR) expression with response to treatment in these patients.

OUTLINE: This is a non-randomized study. Patients are stratified according to epidermal growth factor receptor status (positive vs negative).

Patients receive oral erlotinib once daily. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.

PROJECTED ACCRUAL: A total of 18-48 patients (9-24 per stratum) will be accrued for this study within 2 years.

Study Design

Allocation: Non-Randomized, Control: Active Control, Primary Purpose: Treatment

Conditions

Esophageal Cancer

Intervention

erlotinib hydrochloride

Location

Memorial Sloan-Kettering Cancer Center
New York
New York
United States
10021

Status

Completed

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:47-0400

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PubMed Articles [13860 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

A quinazoline derivative and ANTINEOPLASTIC AGENT that functions as a PROTEIN KINASE INHIBITOR for EGFR associated tyrosine kinase. It is used in the treatment of NON-SMALL CELL LUNG CANCER.

Tumors or cancer of the ESOPHAGUS.

A pathological condition characterized by the presence of a number of ESOPHAGEAL DIVERTICULA in the ESOPHAGUS.

Surgical incision of the lower esophageal sphincter near the CARDIA often used to treat ESOPHAGEAL ACHALASIA.

Circular innermost layer of the ESOPHAGUS wall that mediates esophageal PERISTALSIS which pushes ingested food bolus toward the stomach.

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