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The purpose of this study is to determine if YM872 in combination with t-PA can reduce disability and brain damage from stroke. YM872 or placebo will be given as a continuous intravenous (iv) infusion for 24 hours. It is important that the study medication, YM872 or placebo, is administered prior to the completion of the t-PA administration. The clinical effects of YM872 in addition to t-PA will be determined by assessing neurological function and disability scores at follow up visits through Day 90 of the study.
Allocation: Randomized, Control: Placebo Control, Masking: Double-Blind, Primary Purpose: Treatment
Acute Ischemic Stroke
YM872 (zonampanel), t-PA (alteplase)
University of South Alabama Stroke Center
Astellas Pharma Inc
Published on BioPortfolio: 2014-08-27T03:55:52-0400
This study will investigate the effects of a potential neuroprotectant compound, YM872, in the treatment of acute ischemic stroke. The study will determine if a 24-hour infusion of YM872,...
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Restoration of functions to the maximum degree possible in a person or persons suffering from a stroke.
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