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PURPOSE: Phase II trial to study the effectiveness of visilizumab in treating patients who have graft-versus-host disease following donor peripheral stem cell transplantation that has not responded to previous treatment.
- Determine the survival rate at 180 days after treatment with visilizumab (Nuvion) as second-line therapy in patients with glucocorticoid-refractory acute graft-versus-host disease after prior allogeneic hematopoietic stem cell transplantation.
- Determine the safety of this drug in these patients.
- Determine the clinical response in patients treated with this drug.
OUTLINE: This is a multicenter study.
Patients receive visilizumab (Nuvion) IV for 1-2 doses.
PROJECTED ACCRUAL: A total of 80 patients will be accrued for this study.
Primary Purpose: Supportive Care
Graft Versus Host Disease
City of Hope Comprehensive Cancer Center
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:55:53-0400
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