Advertisement

Topics

Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity

2014-08-27 03:55:54 | BioPortfolio

Summary

This study seeks to document differences in nasal irritant sensitivity within the population. The investigators are interested in knowing whether age, gender, and allergy status (nasal allergies) predict nasal irritant sensitivity. This is important in understanding symptom reporting patterns in air pollution situations (particularly in so-called "problem buildings"), as well as in understanding the reflex mechanism of a response of the nose to irritants (e.g., nasal congestion).

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Single Blind

Conditions

Rhinitis, Allergic, Nonseasonal

Intervention

Nasal irritation thresholds and irritant provocation

Location

Upper Airway Biology Laboratory
Richmond
California
United States
94804

Status

Completed

Source

National Institute of Environmental Health Sciences (NIEHS)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:54-0400

Clinical Trials [1333 Associated Clinical Trials listed on BioPortfolio]

A Pilot Study In Adults And Adolescents With Irritant (Non-Allergic) Rhinitis

The purpose of this pilot study is to compare the effects (effectiveness and safety)of an intranasal corticosteroid (fluticasone furoate nasal spray [FFNS]) with a placebo nasal spray for ...

The Prevalence and Clinical Characteristics of Children With Local Allergic Rhinitis

- To determine prevalence of local allergic rhinitis (LAR) - To evaluate clinical characteristic and severity of local allergic rhinitis - To measure changing of tryptase and Spec...

Intranasal Capsaicin Treatment for Non-Allergic Irritant Rhinitis

The proposed study seeks to investigate the effect of intranasal capsaicin treatment in patient with Non-allergic irritant rhinitis (NAIR), as well as evaluate optical rhinometry (ORM) as ...

Study In Adults And Adolescents With Seasonal Allergic Rhinitis

Compare the efficacy and safety of an investigational nasal spray compared with placebo nasal spray in the treatment of seasonal allergic rhinitis. Allergic rhinitis is an inflammatory dis...

Study of GW685698X In Patients With Seasonal Allergic Rhinitis

This study was designed to compare the efficacy and safety of an investigational nasal spray compared with placebo nasal spray and commonly used drug in the treatment of seasonal allergic ...

PubMed Articles [1800 Associated PubMed Articles listed on BioPortfolio]

miR-375 prevents nasal mucosa cells from apoptosis and ameliorates allergic rhinitis via inhibiting JAK2/STAT3 pathway.

This study aims to explore the roles, and related mechanisms of miR-375 in nasal mucosa cells apoptosis and allergic rhinitis. Here, miR-375 was found to be decreased in the epithelia of nasal mucosa ...

Endotyping of non-allergic, allergic and mixed rhinitis patients using a broad panel of biomarkers in nasal secretions.

Endotyping chronic rhinitis has proven hardest for the subgroup of non-allergic rhinitis (NAR) patients. While IgE-related inflammation is typical for allergic rhinitis (AR), no markers have been foun...

Intranasal Administration of IL-27 Ameliorates Nasal Allergic Responses and Symptoms.

Interleukin 27 (IL-27) is an initiator of the Th1 response and inhibits inflammatory responses. In a mouse model of asthma, administration of IL-27 reduced eosinophil numbers in bronchoalveolar lavage...

Non-allergic rhinitis with eosinophilic syndrome. Case report.

Rhinitis is the leading cause for consultation in the allergy department. It consists in chronic inflammation of the nasal mucosa. Non-allergic rhinitis with eosinophilic syndrome is characterized by ...

Cryosurgery in the treatment of allergic and non-allergic rhinitis.

Introduction: Pharmacological treatment of both allergic and non-allergic rhinitis is not always effective. The aim: Assessment of the effectiveness of treatment of patients with allergic and non-alle...

Medical and Biotech [MESH] Definitions

Application of allergens to the nasal mucosa. Interpretation includes observation of nasal symptoms, rhinoscopy, and rhinomanometry. Nasal provocation tests are used in the diagnosis of nasal hypersensitivity, including RHINITIS, ALLERGIC, SEASONAL.

Diagnostic measurement of the nose and its cavity through acoustic reflections. Used to measure nasal anatomical landmarks, nasal septal deviation, and nasal airway changes in response to allergen provocation tests (NASAL PROVOCATION TESTS).

A form of non-allergic rhinitis that is characterized by nasal congestion and posterior pharyngeal drainage.

A group of symptoms that are two- to three-fold more common in those who work in large, energy-efficient buildings, associated with an increased frequency of headaches, lethargy, and dry skin. Clinical manifestations include hypersensitivity pneumonitis (ALVEOLITIS, EXTRINSIC ALLERGIC); allergic rhinitis (RHINITIS, ALLERGIC, PERENNIAL); ASTHMA; infections, skin eruptions, and mucous membrane irritation syndromes. Current usage tends to be less restrictive with regard to the type of building and delineation of complaints. (From Segen, Dictionary of Modern Medicine, 1992)

Allergic rhinitis that occurs at the same time every year. It is characterized by acute CONJUNCTIVITIS with lacrimation and ITCHING, and regarded as an allergic condition triggered by specific ALLERGENS.

More From BioPortfolio on "Nasal Irritation Study: Individual Factors in Nasal Irritant Sensitivity"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Allergies
The term allergy is used to describe a response, within the body, to a substance, which is not necessarily harmful in itself, but results in an immune response and a reaction that causes symptoms and disease in a predisposed person, which in turn can cau...

Nutrition
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...


Searches Linking to this Trial