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Effectiveness and Safety of INGN 201 in Combination With Chemotherapy Versus Chemotherapy Alone

2014-08-27 03:55:58 | BioPortfolio

Summary

There is a need for more treatment options for patients with recurrent squamous cell cancer of the head and neck (SCCHN). These tumors usually have a variety of genetic defects that include disruption of the p53 pathway, a pathway that would ordinarily work to prevent the development of tumors. In this study the transfer of the p53 gene to tumor cells using a modified adenovirus (INGN 201) in combination with chemotherapy (cisplatin and fluorouracil) will be compared to chemotherapy with cisplatin and fluorouracil in patients who have failed surgery and radiotherapy.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Carcinoma, Squamous Cell

Intervention

INGN 201

Location

University of Arkansas
Little Rock
Arkansas
United States
72205

Status

Recruiting

Source

Introgen Therapeutics

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:58-0400

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