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RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die.
- Determine whether epothilone B can produce a significant response (complete response (CR) or partial response (PR)) as measured by tumor shrinkage in patients with advanced renal cancer.
- Determine the objective response rate and duration of response in patients with CR or PR after treatment with this drug.
- Determine the time to disease progression and overall survival in patients treated with this drug.
- Determine the safety and tolerability of this drug in these patients.
- Determine genetic factors related to renal cancer that may predict response in patients treated with this drug.
- Determine relative susceptibility to drug-drug interactions or serious side effects in patients treated with this drug.
OUTLINE: This is a multicenter study.
Patients receive epothilone B IV over 5 minutes once weekly for three weeks. Courses repeat every 4 weeks in the absence of disease progression or unacceptable toxicity.
Patients are followed at 1 week and then every three months thereafter.
PROJECTED ACCRUAL: Approximately 48 patients will be accrued for this study.
Masking: Open Label, Primary Purpose: Treatment
Jonsson Comprehensive Cancer Center, UCLA
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:55:58-0400
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