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Development of Human Laboratory Study Model of Cocaine Relapse Prevention. - 1

2014-08-27 03:55:59 | BioPortfolio

Summary

The purpose of this study is to assess the development of human laboratory study model of cocaine relapse prevention.

Description

The primary objective of this study will be to develop experimental procedures and parameters demonstrating arousal and craving responses to cocaine-related environmental cues as a model for future testing of the relapse prevention medication treatment of cocaine addiction.

Study Design

Control: Placebo Control, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Cocaine-Related Disorders

Intervention

Cocaine (IV)

Location

UCLA Integrated Substance Abuse Program
Los Angeles
California
United States
90024

Status

Active, not recruiting

Source

National Institute on Drug Abuse (NIDA)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:59-0400

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Medical and Biotech [MESH] Definitions

Disorders related or resulting from use of cocaine.

The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.

An alkaloid ester extracted from the leaves of plants including coca. It is a local anesthetic and vasoconstrictor and is clinically used for that purpose, particularly in the eye, ear, nose, and throat. It also has powerful central nervous system effects similar to the amphetamines and is a drug of abuse. Cocaine, like amphetamines, acts by multiple mechanisms on brain catecholaminergic neurons; the mechanism of its reinforcing effects is thought to involve inhibition of dopamine uptake.

Any of several South American shrubs of the Erythroxylon genus (and family) that yield COCAINE; the leaves are chewed with alum for CNS stimulation.

Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.

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