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Assessment of Potential Interactions Between Methamphetamine and Bupropion - 1

2014-08-27 03:55:59 | BioPortfolio

Summary

The purpose of this study is to assess potential interactions between intravenous (IV) methamphetamine and oral bupropion.

Description

This is a human laboratory clinical pharmacology study to assess potential interactions between IV methamphetamine challenge and treatment with oral sustained-release bupropion.

Study Design

Allocation: Randomized, Control: Placebo Control, Masking: Double-Blind, Primary Purpose: Diagnostic

Conditions

Amphetamine-Related Disorders

Intervention

Bupropion

Location

UCLA Integrated Substance Abuse Program
Los Angeles
California
United States
90024

Status

Active, not recruiting

Source

National Institute on Drug Abuse (NIDA)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:55:59-0400

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Medical and Biotech [MESH] Definitions

Disorders related or resulting from use of amphetamines.

These disorders are related to both SCHIZOPHRENIA SPECTRUM AND RELATED DISORDERS and DEPRESSIVE DISORDERS in terms of symptomatology, family history, and genetics. (DSM-V) .

Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.

A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

Disorders related or resulting from abuse or mis-use of opioids.

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