Phase 2 Study of TLK286 in Metastatic Breast Cancer

2014-08-27 03:56:07 | BioPortfolio


The purpose of this study is to determine the effectiveness of TLK286 in treatment of metastatic breast cancer.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment


Breast Neoplasms




Arizona Cancer Center
United States





Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:56:07-0400

Clinical Trials [2534 Associated Clinical Trials listed on BioPortfolio]

Phase 2 Study of TLK286 in Platinum Resistant Advanced Epithelial Ovarian Cancer

The purpose of this study is to determine the effectiveness and safety of TLK286 given intravenously once every week in the treatment of patients with advanced ovarian cancer that is resis...

TLK286 (Telcyta) vs. Doxil/Caelyx or Hycamtin in Platinum Refractory or Resistant Ovarian Cancer

The purpose of this study is to demonstrate superiority in survival in favor of TLK286 as compared to active control therapy with Doxil/Caelyx or Hycamtin in the intent-to-treat (ITT) popu...

TLK286 in Combination With Paraplatin (Carboplatin) in Recurrent Ovarian Cancer

This is a dose-ranging, open label, Phase 1-2a study of TLK286 in combination with Paraplatin (carboplatin) in patients with recurrent ovarian cancer.

TLK286 in Combination With Doxil in Platinum Refractory or Resistant Ovarian Cancer

This is a dose-ranging, open-label, Phase 1-2a study of TLK286 in combination with Doxil in patients with platinum refractory or resistant ovarian cancer.

Phase 2 Study of TLK286 Administered Weekly in Advanced Non-Small Cell Lung Cancer

The purpose of this study is to determine the effectiveness of TLK286 in the treatment of advanced non-small cell lung cancer.

PubMed Articles [3604 Associated PubMed Articles listed on BioPortfolio]

Fine-needle Aspiration Cytology to Identify a Rare Mimicker of Breast Cancer: Plasma Cell Mastitis.

There are rare benign diseases that can mimic malignant breast neoplasms in the clinical exam and in mammography. We evaluated the contribution of an accessible procedure to most clinicians, the fine-...

Metastatic breast Cancer simulating well-differentiated neuroendocrine neoplasms of visceral organs.

A series of metastatic breast carcinoma (MBC) mimicking visceral well-differentiated neuroendocrine neoplasms has not previously been reported. We identified five consultation cases originally submitt...

Serum levels of activins, follistatins and growth factors in neoplasms of the breast: A case-control study.

Breast cancer is the most common malignancy in women. Non- invasive biomarkers are needed for its early diagnosis and/or prognosis.

CRTC1-MAML2 Fusion in Mucoepidermoid Carcinoma of the Breast.

Mucoepidermoid carcinomas (MEC) are the most common malignant neoplasms of salivary glands but are uncommon in other sites. Salivary gland MEC are most frequently associated with CRTC1-MAML2 transloca...

Relationship between food perceptions and health-related quality of life in a prospective study with breast cancer patients undergoing chemotherapy.

To correlate the perceptions related to dietary intake with the domains and subscales of health-related quality of life (HRQL) in women with breast neoplasms receiving chemotherapy.

Medical and Biotech [MESH] Definitions

Breast neoplasms that do not express ESTROGEN RECEPTORS; PROGESTERONE RECEPTORS; and do not overexpress the NEU RECEPTOR/HER-2 PROTO-ONCOGENE PROTEIN.

Any neoplasms of the male breast. These occur infrequently in males in developed countries, the incidence being about 1% of that in females.

Neoplasms, usually carcinoma, located within the center of an organ or within small lobes, and in the case of the breast, intraductally. The emphasis of the name is on the location of the neoplastic tissue rather than on its histological type. Most cancers of this type are located in the breast.

Metastatic breast cancer characterized by EDEMA and ERYTHEMA of the affected breast due to LYMPHATIC METASTASIS and eventual obstruction of LYMPHATIC VESSELS by the cancer cells.

Tumors or cancer of the human BREAST.

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