Radiofrequency Ablation in Treating Patients With Bone Metastases

2014-08-27 03:56:32 | BioPortfolio


RATIONALE: Radiofrequency ablation may be effective in decreasing pain from bone metastases.

PURPOSE: Phase I/II trial to study the effectiveness of radiofrequency ablation in decreasing pain in patients who have bone metastases.



- Determine the side effects of radiofrequency ablation in patients with bone metastases.

- Determine the effect of this regimen on pain in these patients.

- Determine the effect of this regimen on mood in these patients.

- Determine the effects of narcotic usage in patients treated with this regimen.

- Determine the relationship between laboratory and imaging features of this treatment and the effects of the treatment in these patients.

OUTLINE: This is a multicenter study.

Patients undergo percutaneous CT-guided radiofrequency ablation directly to the metastatic lesion over approximately 12 minutes.

Pain and mood are assessed at baseline, daily for 14 days after treatment, and at 1 and 3 months after treatment.

Patients are followed at 1 week and then at 1 and 3 months.

PROJECTED ACCRUAL: Approximately 75 patients will be accrued for this study within 12.5 months.

Study Design

Masking: Open Label, Primary Purpose: Treatment


Metastatic Cancer


pain therapy, radiofrequency ablation


Comprehensive Cancer Center at University of Alabama at Birmingham
United States


Active, not recruiting


National Cancer Institute (NCI)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:56:32-0400

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