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Radiofrequency Ablation in Treating Patients With Bone Metastases

2014-08-27 03:56:32 | BioPortfolio

Summary

RATIONALE: Radiofrequency ablation may be effective in decreasing pain from bone metastases.

PURPOSE: Phase I/II trial to study the effectiveness of radiofrequency ablation in decreasing pain in patients who have bone metastases.

Description

OBJECTIVES:

- Determine the side effects of radiofrequency ablation in patients with bone metastases.

- Determine the effect of this regimen on pain in these patients.

- Determine the effect of this regimen on mood in these patients.

- Determine the effects of narcotic usage in patients treated with this regimen.

- Determine the relationship between laboratory and imaging features of this treatment and the effects of the treatment in these patients.

OUTLINE: This is a multicenter study.

Patients undergo percutaneous CT-guided radiofrequency ablation directly to the metastatic lesion over approximately 12 minutes.

Pain and mood are assessed at baseline, daily for 14 days after treatment, and at 1 and 3 months after treatment.

Patients are followed at 1 week and then at 1 and 3 months.

PROJECTED ACCRUAL: Approximately 75 patients will be accrued for this study within 12.5 months.

Study Design

Masking: Open Label, Primary Purpose: Treatment

Conditions

Metastatic Cancer

Intervention

pain therapy, radiofrequency ablation

Location

Comprehensive Cancer Center at University of Alabama at Birmingham
Birmingham
Alabama
United States
35294

Status

Active, not recruiting

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:56:32-0400

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Medical and Biotech [MESH] Definitions

The application, via IMPLANTED ELECTRODES, of short bursts of electrical energy in the radiofrequency range, interspersed with pauses in delivery of the current long enough to dissipate the generated heat and avoid heat-induced tissue necrosis.

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