Developmental Effects On Children Of Women Who Take Antiepileptic Drugs During Pregnancy

2014-07-23 21:55:44 | BioPortfolio


The purpose of this study is to determine if antiepileptic drugs (AEDs) differ in their neurodevelopmental effects. Specifically, do the children of the women with epilepsy differ in their behavioral and cognitive development depending on which AED their mother takes during pregnancy?


This is a prospective investigation enrolling 285 to 380 women with epilepsy during the first two trimesters of their pregnancies. There are 25 clinical centers as well as the database center. The women will be taking one of the following AEDs: carbamazepine, phenytoin, valproate, or lamotrigine. Cognitive and behavioral testing of the child will be done up to the age of 6 years. The study does not change the woman's doctor and does not interfere with the care of the treating physician.

Study Design

Observational Model: Family-Based, Time Perspective: Prospective




Differential Abilities Scale, Neuropsychological Testing


University of Alabama
United States


Active, not recruiting


Emory University

Results (where available)

View Results


Published on BioPortfolio: 2014-07-23T21:55:44-0400

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