Treatment Effects on Platelet Calcium in Hypertensive and Depressed Patients

2014-08-27 03:56:48 | BioPortfolio


This study aims to determine if treatment with an SSRI antidepressant medication, paroxetine, is associated with cellular calcium response to serotonin, platelet serotonin receptors, and improvement in mood in depressed patients with or without hypertension. It is hypothesized that platelets of hypertensive patients with depressive symptomatology with be hyper-responsive to serotonin. Additionally, treatment with an SSRI antidepressant is expected to produce a down-regulation of the serotonin receptor with an associated reduction in platelet cytosolic calcium response as well as improved mood.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Double-Blind, Primary Purpose: Treatment




paroxetine, ongoing psychological screening


Edward Hines Jr. Hospital
United States




Department of Veterans Affairs

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:56:48-0400

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