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Bevacizumab, Cytarabine, and Mitoxantrone on Treating Patients With Hematologic Cancers

2014-08-27 03:56:55 | BioPortfolio

Summary

RATIONALE: Monoclonal antibodies such as bevacizumab can locate cancer cells and either kill them or deliver cancer-killing substances to them without harming normal cells. Combining monoclonal antibody therapy with chemotherapy may be an effective treatment for hematologic cancer.

PURPOSE: Phase II trial to study the effectiveness of bevacizumab combined with cytarabine and mitoxantrone in treating patients who have hematologic cancer.

Description

OBJECTIVES:

- Determine the clinical effectiveness of bevacizumab, cytarabine, and mitoxantrone in patients with poor-risk hematologic malignancies.

- Determine the toxic effects of this regimen in these patients.

- Determine whether this regimen can induce cell apoptosis in these patients.

- Determine the effects of bevacizumab on coagulation profiles in these patients.

OUTLINE: This is a multicenter study.

Patients receive cytarabine IV continuously over 72 hours on days 1-3, mitoxantrone IV over 30-60 minutes on day 4, and bevacizumab IV over 90 minutes on day 8 in the absence of disease progression or unacceptable toxicity. Patients achieving partial or complete remission may receive a second course of therapy beginning approximately 30 days after the completion of the first course.

Patients are followed until death.

PROJECTED ACCRUAL: A total of 12-45 patients will be accrued for this study within 1-3 years.

Study Design

Primary Purpose: Treatment

Conditions

Leukemia

Intervention

bevacizumab, cytarabine, mitoxantrone hydrochloride

Location

Blood and Marrow Transplant Group of Georgia
Atlanta
Georgia
United States
30342-1601

Status

Completed

Source

University of Maryland

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:56:55-0400

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Medical and Biotech [MESH] Definitions

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