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Ozone and Rhinovirus-Induced Disease in Asthmatics

2014-08-27 03:57:01 | BioPortfolio

Summary

In the U.S., morbidity associated with human rhinovirus (RV) infection represents a major health problem. In asthmatics, up to 80% of asthma exacerbations are associated with upper respiratory infections. Despite evidence that environmental oxidant pollutants, such as ozone, may increase the severity of viral disease, the mechanisms underlying such an effect have not been identified. This study will test the hypothesis that exposure of allergic asthmatic subjects to ambient levels of ozone directly enhances viral disease by increasing infectivity and intensifying virus-induced inflammation.

Description

In mild asthmatics, the study will investigate: (1) if exposure to ozone will enhance the viral infective process in the nasal epithelium, (2) the effect of ozone exposure on RV-induced inflammatory gene expression, mediator release and inflammatory cell influx into the upper and lower airways, and (3) the interactive effects of ozone and RV on airway reactivity. This information will improve our understanding of the risk associated with oxidant pollutant exposure in this population of individuals in whom RV infection may represent a significant health concern.

Study Design

Time Perspective: Prospective

Conditions

Asthma

Location

The Johns Hopkins School of Hygiene and Public Health
Baltimore
Maryland
United States
21205

Status

Completed

Source

National Institute of Environmental Health Sciences (NIEHS)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:57:01-0400

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