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Chronic Pain After Amputation

2014-07-23 21:56:19 | BioPortfolio

Summary

This trial will test the effectiveness of amitriptyline in relieving chronic pain of adults that have had an amputation

Description

This double-masked placebo controlled trial will randomize patients (n=125) who are 6 months or more after amputation and have a 3 or more month history of pain to a daily dose of amitriptyline or a placebo for 6 weeks. Patients will receive a complete functional neurological examination by one of the study physicians or nurses masked to their treatment assignment. Study participants will also be interviewed by telephone to assess pain, pain interference with activities, physical and mental health, and number of health care visits for pain, at the beginning and end of the six-week trial and four months later.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Double-Blind, Primary Purpose: Treatment

Conditions

Amputation, Traumatic

Intervention

Amitriptyline

Location

University of Washington, Department of Rehabilitation Medicine
Seattle
Washington
United States
98195

Status

Active, not recruiting

Source

Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:56:19-0400

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Medical and Biotech [MESH] Definitions

Loss of a limb or other bodily appendage by accidental injury.

The part of a limb or tail following amputation that is proximal to the amputated section.

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