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Tipifarnib in Treating Patients With Advanced Hematologic Cancer

2014-07-24 14:35:24 | BioPortfolio

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die.

PURPOSE: Randomized phase I trial to study the effectiveness of tipifarnib in treating patients who have advanced hematologic cancer.

Description

OBJECTIVES:

- Determine the relationship between tipifarnib dose and inhibition of farnesylation in malignant cells of patients with advanced hematologic malignancies.

- Determine the safety profile of this drug in this patient population.

- Determine the clinical activity of this drug in these patients.

OUTLINE: This is a randomized study. Patients are randomized to 1 of 4 dose levels.

Patients receive oral tipifarnib twice daily for 21 days. Courses repeat every 28 days in the absence of disease progression or unacceptable toxicity. After 1 course of therapy, patients may receive subsequent therapy at the maximum tolerated dose at the investigator's discretion.

PROJECTED ACCRUAL: A total of 32-36 patients will be accrued for this study within 16 months.

Study Design

Allocation: Randomized, Control: Active Control, Primary Purpose: Treatment

Conditions

Chronic Myeloproliferative Disorders

Intervention

tipifarnib

Location

University of Chicago Cancer Research Center
Chicago
Illinois
United States
60637-1470

Status

Completed

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:35:24-0400

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