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Rebeccamycin Analogue in Treating Women With Stage IIIB or Stage IV Breast Cancer

2014-08-27 03:57:38 | BioPortfolio

Summary

RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. The best way to give rebeccamycin analog in breast cancer patients is not yet known.

PURPOSE: Randomized phase II trial to compare the effectiveness of two regimens of rebeccamycin analogue in treating women who have stage IIIB or stage IV breast cancer.

Description

OBJECTIVES:

- Compare the effectiveness and toxicity of rebeccamycin analogue, administered in 2 different schedules, in women with stage IIIB or IV breast cancer.

OUTLINE: This is a randomized, multicenter study. Patients are randomized to one of two treatment arms.

- Arm I: Patients receive rebeccamycin analogue IV over 60 minutes on day 1.

- Arm II: Patients receive rebeccamycin analogue IV over 60 minutes on days 1-5. Courses repeat every 21 days in the absence of disease progression or unacceptable toxicity.

PROJECTED ACCRUAL: A total of 42 patients (21 per treatment arm) will be accrued for this study within 14-21 months.

Study Design

Allocation: Randomized, Control: Active Control, Primary Purpose: Treatment

Conditions

Breast Cancer

Intervention

becatecarin

Location

Dana-Farber Cancer Institute
Boston
Massachusetts
United States
02115

Status

Completed

Source

National Cancer Institute (NCI)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:57:38-0400

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