Muscatine Heart Study

2014-08-27 03:58:01 | BioPortfolio


To conduct longitudinal and cross-sectional studies of risk factors for coronary heart disease and hypertension in school age children and adults who had been examined in previous screens.



Longitudinal studies of coronary risk factors beginning in subjects at adult age have shown that hypertension, hypercholesterolemia, and obesity are related to the risk of coronary artery disease and stroke. The Framingham Study has shown, in adults over 30 years of age, a positive association between risk of cardiovascular disease and low density lipoprotein cholesterol, elevated systolic blood pressure and diabetes, and a negative association with high density lipoprotein cholesterol.

In 1971 when the Muscatine Heart Study was initiated, there was preliminary evidence that these processes began in childhood. It was noted that children's lipids, blood pressures, and body size maintained a degree of rank order over time, suggesting that those with high levels were likely to become adults with high levels. Whether elevated levels in children of the accepted adult coronary risk factors were predictive of future cardiovascular disease morbidity and mortality remained an important unanswered question.

No data were available which directly linked overt cardiovascular disease to childhood measures of risk factors. The Muscatine study followed children from their school age years into middle age. This study, for the first time, directly related multiple observations of levels and profiles of change in coronary risk factors during childhood to levels of these risk factors measured at ages when the levels had established predictive significance for the development of premature atherosclerotic heart disease.

The Muscatine Heart Study was funded over the years by a Specialized Center of Research (SCOR) in Arteriosclerosis. The SCOR program was initiated by the NHLBI to expedite the development and application of new knowledge essential for improved diagnosis, treatment, and prevention of arteriosclerosis, ischemic heart disease, hypertension, pulmonary disease, and thrombosis. The Muscatine Heart Study was also funded by R01HL35600.

Several substudies were conducted using the Muscatine study population. The subproject on left ventricular mass in childhood was designed to determine the age/sex distribution of left ventricular mass in children 5-14 years of age and whether elevated left ventricular mass, as demonstrated by echocardiography, could be related to higher ambulatory blood pressure, exercise blood pressure and work capacity, or physical conditioning. The study also determined whether there was a familial aggregation of left ventricular mass, whether it was associated with high blood pressure in parents and whether left ventricular mass in children was associated with increased cardiovascular and all causes mortality in first and second degree relatives.

Two subprojects were conducted on the determinants of blood pressure during childhood. Both investigated factors related to blood pressure in groups of children whose blood pressure patterns had been documented over a period of four to 10 years. Five groups of children were identified for study: a group with persistently high pressure; a group with rising blood pressure; a group with decreasing pressure; a group with persistently low pressure; and a group with labile high blood pressure.

The first subproject studied cardiac output, systemic vascular resistance, echocardiographic dimensions, responses to exercise and to mental stress in these groups of children. The purpose of this study was to define whether there were significant differences in blood pressure control during rest, exercise and mental stress in these groups and to determine whether differences in left ventricular wall mass resulted in these groups. The second subproject studied blood pressure control mechanisms in a free-living sample of these five groups while they consumed usual, high and low salt diets. Measurements were made of baroreflex control, structural component of vascular resistance, and response to mental stress. The purpose of this study was to define whether salt sensitivity existed in school children and how it expressed itself on blood pressure control mechanisms.

Studies were also conducted on apolipoproteins in childhood to determine their role as a risk factor and apolipoprotein A-I and A-II gene polymorphisms and their associations with alterations in high density lipoprotein levels and risk of coronary artery disease.


The design was both cross-sectional and longitudinal. Between 1971 and 1986, over 13,000 school age children from 5 to 18 years of age were screened for coronary risk factors. Measurements were made of serum cholesterol, serum triglycerides, blood pressure, height, weight, and skinfold thickness. Beginning in 1980 the graduates of the Muscatine schools who had participated in earlier screens were recruited at ages 23, 28, 33, and 38 years to have their risk factors re-assessed. The oldest graduates were 38 years of age by 1991. The total number of adults was 5,126.

Study Design

Observational Model: Natural History


Cardiovascular Diseases




National Heart, Lung, and Blood Institute (NHLBI)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:58:01-0400

Clinical Trials [1280 Associated Clinical Trials listed on BioPortfolio]

Cardiovascular Diseases in HIV-infected Subjects (HIV-HEART Study)

Human immunodeficiency virus (HIV) infection has been associated with a variety of cardiovascular diseases. Even most industrialised countries exhibit a growing and aging population of HIV...

The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases

This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitatio...

ARROW:identificAtion of postpRandial biomaRkers tOWards Cardiovascular Prevention

The purpose of this study is to better understand the association between the postprandial biomarker responses after a food challenge with the development of cardiovascular diseases in hea...

Development, Testing, and Validation of A Protocol To Assess Cardiovascular Reactivity in Human Populations

To develop a comprehensive protocol for assessing cardiovascular reactivity to stressors, for use in epidemiological and clinical investigations of cardiovascular diseases in healthy popul...

Cardiovascular Diseases in the Silesian Region in Poland.

The Silesian Cardiovascular Database is an observational study of all patients hospitalized due to cardiovascular diseases. The date include information on the clinical characteristics, tr...

PubMed Articles [11613 Associated PubMed Articles listed on BioPortfolio]

Introduction and Update on Obesity and Cardiovascular Diseases 2018.

Pharmacological Modulation of Vagal Nerve Activity in Cardiovascular Diseases.

Cardiovascular diseases are life-threatening illnesses with high morbidity and mortality. Suppressed vagal (parasympathetic) activity and increased sympathetic activity are involved in these diseases....

Human Emotions on the Onset of Cardiovascular and Small Vessel Related Diseases.

The aim of the present study was to examine the relation between understanding of emotions and cardiovascular related diseases, namely coronary heart disease, diabetes mellitus and obesity. The unique...

Endothelial function and dysfunction: impact of metformin.

Cardiovascular and metabolic diseases remain the leading cause of morbidity and mortality worldwide. Endothelial dysfunction is a key player in the initiation and progression of cardiovascular and met...

Perturbation of metabolic pathways mediates the association of air pollutants with asthma and cardiovascular diseases.

Epidemiologic evidence indicates common risk factors, including air pollution exposure, for respiratory and cardiovascular diseases, suggesting the involvement of common altered molecular pathways.

Medical and Biotech [MESH] Definitions

Pathological conditions involving the CARDIOVASCULAR SYSTEM including the HEART; the BLOOD VESSELS; or the PERICARDIUM.

Methods and procedures for the diagnosis of diseases or dysfunction of the cardiovascular system or its organs or demonstration of their physiological processes.

Diseases of long duration and generally slow progression. The four main types of noncommunicable diseases are CARDIOVASCULAR DISEASES (e.g., heart attacks and stroke), CANCER, chronic respiratory diseases (e.g., CHRONIC OBSTRUCTIVE PULMONARY DISEASE and ASTHMA) and DIABETES MELLITUS.

Unexpected rapid natural death due to cardiovascular collapse within one hour of initial symptoms. It is usually caused by the worsening of existing heart diseases. The sudden onset of symptoms, such as CHEST PAIN and CARDIAC ARRHYTHMIAS, particularly VENTRICULAR TACHYCARDIA, can lead to the loss of consciousness and cardiac arrest followed by biological death. (from Braunwald's Heart Disease: A Textbook of Cardiovascular Medicine, 7th ed., 2005)

Dental care for patients with chronic diseases. These diseases include chronic cardiovascular, endocrinologic, hematologic, immunologic, neoplastic, and renal diseases. The concept does not include dental care for the mentally or physically disabled which is DENTAL CARE FOR DISABLED.

More From BioPortfolio on "Muscatine Heart Study"

Quick Search


Relevant Topics

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...

Pulmonary Hypertension
Pulmonary arterial hypertension (PAH) is a chronic, life-threatening disorder characterized by abnormally high blood pressure in the arteries between the heart and lungs of affected individuals. Symptoms can range from mild breathles...

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Searches Linking to this Trial