Longitudinal and Biological Study of Childhood Disintegrative Disorder

2014-08-27 03:58:14 | BioPortfolio



I. Compare the developmental course (language acquisition, diagnostic stability, predictors of outcome, and restricted interests and behaviors) of childhood disintegrative disorder versus autism and non-autistic developmental delays.

II. Collect data on molecular genetics of proband and family members.



Patients are evaluated with the following questionnaires at ages 2-3 years and again at ages 5-9: The Autism Diagnostic Interview (ADI); The Autism Diagnostic Observation Schedule (ADOS); Assessment of cognitive functioning; Expressive and receptive language; Adaptive functioning; Measures of burden and functional assessment; The Aberrant Behavior Checklist; The Connors Rating Scale - Parent and Teacher version; and Autism Behavior Checklist

An MRI and EEG are performed, and blood samples are collected from patients and family members for molecular genetic studies.

Study Design

Primary Purpose: Screening, Time Perspective: Longitudinal


Pervasive Child Development Disorders


Yale Child Study Center
New Haven
United States




Office of Rare Diseases (ORD)

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:58:14-0400

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Severe distortions in the development of many basic psychological functions that are not normal for any stage in development. These distortions are manifested in sustained social impairment, speech abnormalities, and peculiar motor movements.

A child whose needs, abilities, or other characteristics vary so much from the average in mental, physical, or social areas that a greater than usual level of services is needed to facilitate the child's maximum potential development.

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The language and sounds expressed by a child at a particular maturational stage in development.

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