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RATIONALE: Diagnostic procedures such as thoracoscopy may help to measure a patient's response to previous treatment.
PURPOSE: Diagnostic trial to determine the accuracy of thoracoscopy in patients who have stage IIIA non-small cell lung cancer.
- Evaluate the feasibility of using videothoracoscopy to access and identify residual viable cancer in mediastinal lymph nodes and/or evaluate for other conditions that render patients unresectable (pleural carcinomatosis or T4 primary tumors) following prior mediastinoscopy and a period of neoadjuvant therapy in patients with stage IIIA non-small cell lung cancer.
- Evaluate the safety (morbidity and mortality) of preresectional thoracoscopic restaging of these patients.
- Assess the accuracy (false-negative rate) of thoracoscopic mediastinal node restaging in these patients.
OUTLINE: Patients undergo ipsilateral videothoracoscopic evaluation for restaging their disease after prior mediastinoscopy and induction therapy.
Patients with negative restaging procedures are strongly encouraged to undergo anatomic resection (lobectomy, bilobectomy, or pneumonectomy) with complete mediastinal lymphadenectomy.
Patients with a positive restaging procedure may still undergo resection at the discretion of the surgeon and other treating physicians.
PROJECTED ACCRUAL: A total of 75 patients will be accrued for this study within 30 months.
Primary Purpose: Diagnostic
Northeast Alabama Regional Medical Center
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:58:39-0400
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Tumors or cancer of the LUNG.
Malignant neoplasm arising from the epithelium of the BRONCHI. It represents a large group of epithelial lung malignancies which can be divided into two clinical groups: SMALL CELL LUNG CANCER and NON-SMALL-CELL LUNG CARCINOMA.
Nuclear phosphoprotein encoded by the p53 gene (GENES, P53) whose normal function is to control CELL PROLIFERATION and APOPTOSIS. A mutant or absent p53 protein has been found in LEUKEMIA; OSTEOSARCOMA; LUNG CANCER; and COLORECTAL CANCER.
A heterogeneous aggregate of at least three distinct histological types of lung cancer, including SQUAMOUS CELL CARCINOMA; ADENOCARCINOMA; and LARGE CELL CARCINOMA. They are dealt with collectively because of their shared treatment strategy.
A form of highly malignant lung cancer that is composed of small ovoid cells (SMALL CELL CARCINOMA).
GILOTRIF (afatinib) is a kinase inhibitor indicated for the first-line treatment of patients with metastatic non-small cell lung cancer (NSCLC) whose tumors have epidermal growth factor receptor (EGFR) exon 19 deletions or exon 21 (L8...
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