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RATIONALE: Hyperthermia therapy may kill prostate cancer cells by heating them to several degrees above body temperature. Radiation therapy uses high-energy x-rays to damage tumor cells. Combining hyperthermia with radiation therapy may kill more tumor cells.
- Evaluate the efficacy of hyperthermia and radiation therapy in patients with locally advanced prostate cancer.
- Evaluate the acute and long term toxicities of these therapies in this patient population.
OUTLINE: Patients are treated with external beam irradiation 5 days a week for a total of approximately 7 weeks. Hyperthermia treatment is given twice in the first 4 weeks of radiation therapy, preferably early in the course of radiation. Hyperthermia treatments are only given once a week. A transrectal ultrasound applicator is used to deliver the hyperthermia treatment.
Patients are followed every three months for 2 years, and every 6 months thereafter.
PROJECTED ACCRUAL: Approximately 65 patients will be accrued over 2 years.
Primary Purpose: Treatment
hyperthermia treatment, radiation therapy
Dana-Farber Cancer Institute
Active, not recruiting
National Cancer Institute (NCI)
Published on BioPortfolio: 2014-08-27T03:58:53-0400
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