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Dextroamphetamine as an Adjunct in Cocaine Treatment - 1

2014-08-27 04:00:12 | BioPortfolio

Summary

The purpose of this study is to evaluate dextroamphetamine sulfate (sustained release) as an adjunct in cocaine treatment; an evaluation of the ""replacement"" strategy.

Study Design

Allocation: Randomized, Control: Placebo Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor), Primary Purpose: Treatment

Conditions

Cocaine-Related Disorders

Intervention

Dextroamphetamine, D-Amphetamine, Placebo

Location

University of Texas Health Science Center
Houston
Texas
United States
77225

Status

Completed

Source

National Institute on Drug Abuse (NIDA)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T04:00:12-0400

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PubMed Articles [14638 Associated PubMed Articles listed on BioPortfolio]

False-Positive Dopamine Transporter Imaging Due to Therapeutic Dextroamphetamine/Amphetamine.

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Cocaine-induced multifocal leukoencephalopathy mimicking Balo's concentric sclerosis: A 2-year follow-up with serial imaging of a single patient.

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Examining the Association Between Psychiatric Disorders and Cocaine Binges: Results From the COSMO Study.

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ProSAAS-derived peptides are regulated by cocaine and are required for sensitization to the locomotor effects of cocaine.

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Medical and Biotech [MESH] Definitions

Disorders related or resulting from use of cocaine.

The d-form of AMPHETAMINE. It is a central nervous system stimulant and a sympathomimetic. It has also been used in the treatment of narcolepsy and of attention deficit disorders and hyperactivity in children. Dextroamphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulating release of monamines, and inhibiting monoamine oxidase. It is also a drug of abuse and a psychotomimetic.

Disorders related or resulting from use of amphetamines.

A powerful central nervous system stimulant and sympathomimetic. Amphetamine has multiple mechanisms of action including blocking uptake of adrenergics and dopamine, stimulation of release of monamines, and inhibiting monoamine oxidase. Amphetamine is also a drug of abuse and a psychotomimetic. The l- and the d,l-forms are included here. The l-form has less central nervous system activity but stronger cardiovascular effects. The d-form is DEXTROAMPHETAMINE.

Tricyclic anorexigenic agent unrelated to and less toxic than AMPHETAMINE, but with some similar side effects. It inhibits uptake of catecholamines and blocks the binding of cocaine to the dopamine uptake transporter.

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