Dose Response Trial of Pergolide for Cocaine Dependence - 1
Summary
The purpose of this study is to evaluate the efficacy and safety of pergolide for treatment of cocaine dependence.
Study Design
Primary Purpose: Treatment
Conditions
Cocaine-Related Disorders
Intervention
Pergolide
Location
Medical University of South Carolina
Charleston
South Carolina
United States
29425 742
Status
Completed
Source
National Institute on Drug Abuse (NIDA)
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT00000248
- Information obtained from ClinicalTrials.gov on July 15, 2010
Published on BioPortfolio: 2014-07-23T22:00:26-0400
Clinical Trials
Pergolide Treatment for Substance Abusers - 4
The purpose of this study is to evaluate the safety and efficacy of pergolide for cocaine dependence.
IV Cocaine Abuse: A Laboratory Model - 4
The purpose of this study is to evaluate the effects of pergolide on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate depe...
IV Cocaine Abuse: A Laboratory Model - 3
The purpose of this study is to evaluate the effects of buprenorpine on cocaine taking and on the physiological and subjective effects of cocaine, including cocaine craving in non-opiate d...
Development of Human Laboratory Study Model of Cocaine Relapse Prevention II - 1
To study of classical conditioning mechanisms associated with arousal, craving and cocaine use.
Cocaine Effects in Humans: Physiology and Behavior - 1
The purpose of this study is to compare the effects of buprenorphine or methadone maintenance on cocaine taking and on the physiological and subjective effects of cocaine, including cocain...
PubMed Articles
Attention-deficit hyperactivity disorder (ADHD) is overrepresented among individuals seeking treatment for substance use disorders. We previously reported that treatment with extended release mixed am...
Relevance of treated cocaine users' retrospective memory of first cocaine use.
Little is known regarding between-subject variability in the subjective effects of first cocaine use. This study retrospectively assesses the subjective effects of first cocaine use in 160 current tre...
Bioavailability and Pharmacokinetics of Oral Cocaine in Humans.
The pharmacokinetic profile of oral cocaine has not been fully characterized and prospective data on oral bioavailability are limited. A within-subject study was performed to characterize the bioavail...
Dopamine receptors are implicated in cocaine reward and seeking. We hypothesize that (-)-stepholidine, a dopamine D1/D2/D3 multi-receptor agent, would be effective in reducing cocaine reward and seeki...
Pre-trial cocaine biases choice toward cocaine through suppression of the nondrug option.
Being under the influence during choice between drug and nondrug options can have a dramatic effect on choice outcomes. When rats face a choice between cocaine and sweet water and are not under the in...
Medical and Biotech [MESH] Definitions
Cocaine-related Disorders
Disorders related or resulting from use of cocaine.
Bipolar And Related Disorders
These disorders are related to both SCHIZOPHRENIA SPECTRUM AND RELATED DISORDERS and DEPRESSIVE DISORDERS in terms of symptomatology, family history, and genetics. (DSM-V) .
Crack Cocaine
The purified, alkaloidal, extra-potent form of cocaine. It is smoked (free-based), injected intravenously, and orally ingested. Use of crack results in alterations in function of the cardiovascular system, the autonomic nervous system, the central nervous system, and the gastrointestinal system. The slang term "crack" was derived from the crackling sound made upon igniting of this form of cocaine for smoking.
Substance-related Disorders
Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.
Cocaine Smoking
SMOKING of COCAINE.
