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The purpose of this study is to evaluate the effects of IV dynorphin in humans during acute heroin abstinence, in order to determine that dynorphin suppresses acute opiate withdrawal, reduces opiate craving, and is safe at doses required to produce the above effects.
Randomized double blinded study of the effects of a single IV dose of dynorphin A 1-13 on heroin withdrawal in human opiate addicts
Control: Placebo Control, Masking: Double-Blind, Primary Purpose: Treatment
Dynorphin 1 - 13
U of Minnesota School of Medicine
National Institute on Drug Abuse (NIDA)
Published on BioPortfolio: 2014-08-27T04:00:15-0400
The purpose of this study is to assess the degree in which opioid-dependent outpatients discount the value of an additional maintenance dose of buprenorphine under differing states of opio...
The purpose is to validate the PRISM-5-Op as a measurement of prescription opioid substance use disorder.
Retrospective study to assess incidence and predictors of opioid abuse, addiction, overdose & death among patients prescribed ER/LA opioid products
The purpose of this study is to quantify the serious risks of misuse, abuse, and addiction associated with long-term use of opioid analgesics for management of chronic pain, among patients...
The purpose of this study is to evaluate varying doses of buprenorphine for opioid dependence and cocaine abuse.
Understanding the neural systems that drive alcohol motivation and are disrupted in alcohol use disorders is of critical importance in developing novel treatments. The dynorphin and orexin/hypocretin ...
The diffuse noxious inhibitory controls (DNIC) response is often decreased, or lost, in stress-related functional pain syndromes. As the dynorphin/kappa opioid receptor (KOR) pathway is activated by s...
Amphibian neuromuscular junctions become relatively more silent during the dry-winter season in Australia. Endogenous opioid peptides play an important role in the regulation of the physiological func...
The United States has the ignominious distinction of leading the world in opioid prescribing,and in opioid-related overdose deaths. The Centers for Disease Control (CDC) estimates that over 40,000 peo...
POFA trial study protocol: a multicentre, double-blind, randomised, controlled clinical trial comparing opioid-free versus opioid anaesthesia on postoperative opioid-related adverse events after major or intermediate non-cardiac surgery.
Reducing opioid consumption during and after surgery has been recommended for more than 10 years. Opioid-free anaesthesia (OFA) is a multimodal anaesthesia associating hypnotics, NMDA antagonists, loc...
A class of opioid peptides including dynorphin A, dynorphin B, and smaller fragments of these peptides. Dynorphins prefer kappa-opioid receptors (RECEPTORS, OPIOID, KAPPA) and have been shown to play a role as central nervous system transmitters.
Disorders related or resulting from abuse or mis-use of opioids.
These disorders are related to both SCHIZOPHRENIA SPECTRUM AND RELATED DISORDERS and DEPRESSIVE DISORDERS in terms of symptomatology, family history, and genetics. (DSM-V) .
Disorders related to substance abuse, the side effects of a medication, toxin exposure, and ALCOHOL-RELATED DISORDERS.
A synthetic opioid that is used as the hydrochloride. It is an opioid analgesic that is primarily a mu-opioid agonist. It has actions and uses similar to those of MORPHINE. It also has a depressant action on the cough center and may be given to control intractable cough associated with terminal lung cancer. Methadone is also used as part of the treatment of dependence on opioid drugs, although prolonged use of methadone itself may result in dependence. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1082-3)
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...