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Effect of Intravenous Lidocaine on BIS-guided Propofol Requirements During General Anesthesia

2014-08-27 04:00:24 | BioPortfolio

Summary

The purpose of this randomized clinical trial is to evaluate the interaction of lidocaine infusion initiated and maintained during surgery, on propofol requirements during general anesthesia.

Description

Use of intravenous lidocaine as a coadjuvant agent during general anesthesia has increased. Lidocaine infusion during and after abdominal surgery decreases postoperative pain and reduces ileus duration, reducing patient´s hospital stay and opioid consumption. Intravenous lidocaine´s effect on other intravenous anesthetics is unclear, and there are no present studies evaluating its interaction on hypnotic anesthetic requirements when using a BIS (Bispectral Index) monitor to maintain an adequate depth of anesthesia. We therefore decided to conduct a randomized controlled trial to evaluate the interaction of systemic lidocaine infusion, initiated and maintained during surgery, on propofol requirements and anesthetic depth as measured by BIS.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver, Outcomes Assessor), Primary Purpose: Supportive Care

Conditions

Intravenous Anesthetic Interaction "Unrecognized Condition"

Intervention

Intravenous lidocaine infusion, Placebo (0.9% saline infusion), Propofol 1% (intravenous infusion), Placement of arterial line

Location

Hospital Clínico Pontificia Universidad Católica de Chile
Santiago
RM
Chile
8330024

Status

Completed

Source

Pontificia Universidad Catolica de Chile

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T04:00:24-0400

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