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Regional Citrate Anticoagulation in Plasma Exchange Treatment

2014-08-27 04:00:24 | BioPortfolio

Summary

The investigators want to compare the efficacy of plasma exchange treatment with using two different citrates ( 4% and 15% ) as anticoagulants in plasma exchange treatment.

The efficacy of plasma exchange treatment is better with using 15% trisodium citrate as anticoagulant during the plasma exchange procedure.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Focal Segmental Glomerulosclerosis

Intervention

plasma exchange treatment

Location

Center for acute and complicated dialysis, Clinical department of nephrology, UMC Ljubljana
Ljubljana
Slovenia
1000

Status

Recruiting

Source

University Medical Centre Ljubljana

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T04:00:24-0400

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Medical and Biotech [MESH] Definitions

A clinicopathological syndrome or diagnostic term for a type of glomerular injury that has multiple causes, primary or secondary. Clinical features include PROTEINURIA, reduced GLOMERULAR FILTRATION RATE, and EDEMA. Kidney biopsy initially indicates focal segmental glomerular consolidation (hyalinosis) or scarring which can progress to globally sclerotic glomeruli leading to eventual KIDNEY FAILURE.

An ApoL protein highly expressed by the liver. It has anti-trypanosomal activity through its ability to permeabilize TRYPANOSOMA membranes. Mutations in the APOL1 gene are associated with type 4 FOCAL SEGMENTAL GLOMERULOSCLEROSIS .

A non-selective, calcium permeant TRPC cation channel that contains four ANKYRIN REPEATS and is activated by DIACYLGLYCEROL independently of PROTEIN KINASE C. It is expressed in placenta, lung, spleen, ovary and the small intestine, as well as by PODOCYTES in the kidney glomerulus. Mutations in the TRPC6 gene are associated with FOCAL SEGMENTAL GLOMERULOSCLEROSIS type 2.

Removal of plasma and replacement with various fluids, e.g., fresh frozen plasma, plasma protein fractions (PPF), albumin preparations, dextran solutions, saline. Used in treatment of autoimmune diseases, immune complex diseases, diseases of excess plasma factors, and other conditions.

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