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Outcome Study of Lanthanum Carbonate Compared With Calcium Carbonate in Hemodialysis Patients : Landmark Study

2014-09-16 13:06:00 | BioPortfolio

Summary

The purpose of this study is to demonstrate decrease in cardiovascular mortality and morbidity in Japanese hemodialysis patients treated with Lanthanum carbonate compared with those with Calcium carbonate.

Description

Elevated serum phosphate and calcium in dialysis patients are independently associated with increased risk of arterial calcification and mortality. Calcium-based phosphate binders can induce hypercalcaemia and are associated with progression of vascular calcification. A recent randomized study demonstrated that sevelamer, a non-calcium-based phosphate binders, reduced mortality in elderly hemodialysis patients compared with calcium-based phosphate binders. Lanthanum carbonate is another efficacious and well-tolerated non-calcium phosphate binder. A post-hoc survival analysis of lanthanum carbonate versus standard therapy suggested a survival benefit of lanthanum carbonate treatment for elderly patients.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Hemodialysis

Intervention

Lanthanum Carbonate, Calcium Carbonate

Location

Showa University
Shinagawa
Tokyo
Japan
142-0064

Status

Active, not recruiting

Source

Translational Research Informatics Center, Kobe, Hyogo, Japan

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-09-16T13:06:00-0400

Clinical Trials [1144 Associated Clinical Trials listed on BioPortfolio]

A Long Term Study of Lanthanum Carbonate in Patients Requiring Dialysis Who Have Ived Lanthanum Carbonate in Previous Studies Defined by the Protocol.

The purpose of this study is to assess the safety of lanthanum carbonate in patients undergoing dialysis who have received lanthanum carbonate in the previous studies and wish to continue ...

Pharmacodynamic Study of Two Lanthanum Carbonate Formulations in Healthy Adults

This study is being conducted to assess any potential differences in the absorption and excretion between two lanthanum carbonate formulations. This study is also being done to assess the ...

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The purpose of this study is to assess phosphate reduction and control in patients with End Stage Renal Disease treated with lanthanum carbonate

Different Effects of Non-calcium Phosphate Binders on Serum Calcium

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PubMed Articles [2227 Associated PubMed Articles listed on BioPortfolio]

Case report of lanthanum deposition in the esophagus.

A 69-year-old woman had received hemodialysis for chronic renal failure and was taking lanthanum carbonate since 63 years of age. She presented with appetite loss and nausea. We performed esophagogas...

A Novel OSSO-Type Chromium (III) Complex as Versatile Catalyst for Copolymerization of Carbon Dioxide with Epoxides.

A new chromium(III) complex, bearing a bis-thioether-diphenolate [OSSO]-type ligand, was found to be an efficient catalyst in the copolymerization of CO 2 and epoxides to achieve poly(propylene carbon...

Cell architecture of the giant sulfur bacterium Achromatium oxaliferum: Extra-cytoplasmic localization of calcium carbonate bodies.

Achromatium oxaliferum is a large sulfur bacterium easily recognized by large intracellular calcium carbonate bodies. Although these bodies often fill major parts of the cells' volume their role and s...

Non-stoichiometric hydrated magnesium-doped calcium carbonate precipitation in ethanol.

The effect of Mg2+ on the precipitation pathway of CaCO3 in absolute ethanol has been studied to investigate the role of ion solvation in the crystallization process. Our data reveal that high concent...

Gas-Phase Reactivity of Carbonate Ions with Sulfur Dioxide: an Experimental Study of Clusters Reactions.

The reactivity of carbonate cluster ions with sulfur dioxide has been investigated in the gas phase by mass spectrometric techniques. SO promotes the displacement of carbon dioxide from carbonate clu...

Medical and Biotech [MESH] Definitions

Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.

A field of chemistry which pertains to chemical compounds or ions that do not contain the element carbon (with the exception of carbon dioxide and compounds containing a carbonate radical, e.g., calcium carbonate).

Solutions prepared for hemodialysis. The composition of the pre-dialysis solution may be varied in order to determine the effect of solvated metabolites on anoxia, malnutrition, acid-base balance, etc. Of principal interest are the effect of the choice of buffers (e.g., acetate or carbonate), the addition of cations (Na+, K+, Ca2+), and addition of carbohydrates (glucose).

Lanthanum. The prototypical element in the rare earth family of metals. It has the atomic symbol La, atomic number 57, and atomic weight 138.91. Lanthanide ion is used in experimental biology as a calcium antagonist; lanthanum oxide improves the optical properties of glass.

Protein-mineral complexes that comprise substrates needed for the normal calcium-carbonate-phosphate homeostasis. Nanobacteria was the prior name for the particles which were originally thought to be microorganisms.

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