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RENABLATE Feasibility - EC12-02

2014-08-27 04:00:37 | BioPortfolio

Summary

The RENABLATE study is a prospective, multi-center, non-randomized feasibility study to evaluate the safety and effectiveness of the investigational Celsius® ThermoCool® RD Multi-electrode Ablation Catheter and integrated ablation system to treat resistant hypertension.

Study Design

Endpoint Classification: Safety/Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Renal Denervation

Intervention

Renal Sympathetic Denervation, Celsius® ThermoCool® RD Multi-electrode Ablation Catheter

Location

Peninsula Heart Centre
Frankston
Victoria
Australia
3199

Status

Active, not recruiting

Source

Biosense Webster, Inc.

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T04:00:37-0400

Clinical Trials [2202 Associated Clinical Trials listed on BioPortfolio]

Renal Sympathetic Denervation From the Adventitia on Resistant Hypertension(RSDARH)

As one of the most common chronic diseases,The adult prevalence of hypertension is approximately 26.4% at present and will rise to 29.2% by 2025.Renal sympathetic denervation from the inti...

Renal Sympathetic Denervation From The Adventitia on Hypertension

Renal sympathetic denervation from the intima of renal arteries has become an important method for the treatment of resistant hypertension, but renal sympathetic nerve are mainly located i...

Multi-electrode Radiofrequency Renal Denervation System Feasibility Study

This is a prospective, single-arm, non-randomized and open label feasibility study. The study is intended to evaluate safety and efficacy of multi-electrode radiofrequency renal denervati...

Systemic Microvascular Function in Patients With Resistant Hypertension After Renal Sympathetic Denervation

It has been proposed that the modulation of the activity of the sympathetic nervous system, through renal sympathetic denervation, besides reducing blood pressure, would promote an improve...

Symap Mapping/ Ablation of Renal Nerve Trial

To evaluate the safety and efficacy of targeted renal sympathetic denervation using SyMapCath I™ in patients with pharmacotherapy and uncontrolled hypertension for at least 6 months, the...

PubMed Articles [8070 Associated PubMed Articles listed on BioPortfolio]

Selective ablation of the ligament of Marshall reduces ischemia and reperfusion-induced ventricular arrhythmias.

Cardiac sympathetic tone overdrive is a key mechanism of arrhythmia. Cardiac sympathetic nerves denervation, such as LSG ablation or renal sympathetic denervation, suppressed both the prevalence of VA...

Procedural and anatomical predictors of renal denervation efficacy using two radiofrequency renal denervation catheters in a porcine model.

Several renal denervation (RDN) systems are currently under investigation for treatment of hypertension by ablation of renal sympathetic nerves. The procedural efficacy of devices, however, is variabl...

Renal sympathetic denervation in Sweden: a report from the Swedish registry for renal denervation.

Evaluation of later morphologic alterations in renal artery wall and renal nerves in response to catheter-based renal denervation in sheep: comparison of the single-point and multiple-point ablation catheters.

This study evaluated the subacute morphologic alterations in renal artery wall and renal nerves in response to catheter-based renal denervation in sheep and also compared the efficiency of single-poin...

Atrial fibrillation reduction by renal sympathetic denervation: 12 months' results of the AFFORD study.

The purpose of this pilot study was to assess whether renal sympathetic denervation (RDN) decreases atrial fibrillation (AF) burden in hypertensive patients with symptomatic AF at 6- and 12-month foll...

Medical and Biotech [MESH] Definitions

An electrochemical technique for measuring the current that flows in solution as a function of an applied voltage. The observed polarographic wave, resulting from the electrochemical response, depends on the way voltage is applied (linear sweep or differential pulse) and the type of electrode used. Usually a mercury drop electrode is used.

Removal of tissue by vaporization, abrasion, or destruction. Methods used include heating tissue by hot liquids or microwave thermal heating, freezing (CRYOABLATION), chemical ablation, and photoablation with LASERS.

Ganglia of the sympathetic nervous system including the paravertebral and the prevertebral ganglia. Among these are the sympathetic chain ganglia, the superior, middle, and inferior cervical ganglia, and the aorticorenal, celiac, and stellate ganglia.

Nerve fibers which project from sympathetic ganglia to synapses on target organs. Sympathetic postganglionic fibers use norepinephrine as transmitter, except for those innervating eccrine sweat glands (and possibly some blood vessels) which use acetylcholine. They may also release peptide cotransmitters.

An X-linked inherited metabolic disease caused by a deficiency of lysosomal ALPHA-GALACTOSIDASE A. It is characterized by intralysosomal accumulation of globotriaosylceramide and other GLYCOSPHINGOLIPIDS in blood vessels throughout the body leading to multi-system complications including renal, cardiac, cerebrovascular, and skin disorders.

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Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

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