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Preoperative TPF Chemotherapy in a Population of Molecularly Selected Locally Advanced Resectable Oral Cavity Squamous Cell Cancer

2014-08-27 04:00:43 | BioPortfolio

Summary

This is a phase II study of preoperative chemotherapy with docetaxel, cisplatin and 5-fluorouracil (TPF) in locally advanced resectable oral cavity squamous cell cancer. The aim is to improve the rate of pathological complete response to induction chemotherapy in a molecular enriched population, consisting of patients with tumour harbouring a functional p53 protein and/or showing low expression of beta-tubulin II.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Locally Advanced Resectable Oral Cavity Squamous Cell Cancer

Intervention

docetaxel, cisplatin, 5 fluorouracil

Location

Istituto Nazionale Tumori
Milano
Italy
20133

Status

Recruiting

Source

Fondazione IRCCS Istituto Nazionale dei Tumori, Milano

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T04:00:43-0400

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Medical and Biotech [MESH] Definitions

The oval-shaped oral cavity located at the apex of the digestive tract and consisting of two parts: the vestibule and the oral cavity proper.

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