The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
Summary
This study will help determine if menthol administered by inhalation via electronic cigarettes (e-cigarette) changes the reinforcing effects of pure nicotine administered intravenously in cigarette smokers who smoke mentholated or non-mentholated cigarettes.
Study Design
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)
Conditions
Nicotine Dependence
Intervention
IV nicotine, Tobacco Flavor, Low dose Menthol, High Dose Menthol
Location
VA Connecticut Health Care System
West Haven
Connecticut
United States
06516
Status
Recruiting
Source
Yale University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT02102100
- ClinicalTrials.gov processed this data on April 24, 2014
Published on BioPortfolio: 2014-08-27T04:00:50-0400
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PubMed Articles
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The aim of the study was to assess young adult dual e-cigarette (EC) and combusted cigarette (CC) users' anticipated responses to a hypothetical very low nicotine content product standard and menthol ...
The increased consumption of tobacco products in recent years has been linked, among other factors, to the presence of added flavors. Although flavors are important in explaining consumption, their ef...
Medical and Biotech [MESH] Definitions
Lethal Dose 50
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
Menthol
An alcohol produced from mint oils or prepared synthetically.
Dose Hypofractionation
A treatment schedule in which the total dose of radiation is divided into large doses.
Mice, Inbred Sencar
Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.
Maximum Tolerated Dose
The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)
