The Effects of Menthol as Delivered by an Electronic Cigarette on the Desirability of Nicotine in Tobacco Users
Summary
This study will help determine if menthol administered by inhalation via electronic cigarettes (e-cigarette) changes the reinforcing effects of pure nicotine administered intravenously in cigarette smokers who smoke mentholated or non-mentholated cigarettes.
Study Design
Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator)
Conditions
Nicotine Dependence
Intervention
IV nicotine, Tobacco Flavor, Low dose Menthol, High Dose Menthol
Location
VA Connecticut Health Care System
West Haven
Connecticut
United States
06516
Status
Recruiting
Source
Yale University
Results (where available)
Links
- Source: http://clinicaltrials.gov/show/NCT02102100
- ClinicalTrials.gov processed this data on April 24, 2014
Published on BioPortfolio: 2014-08-27T04:00:50-0400
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PubMed Articles
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Menthol Cigarette use in Young Adult Smokers with Severe Mental Illnesses.
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Currently, capsule cigarettes have been introduced by tobacco industries and their sales have increased exponentially. However, the capsule flavoring ingredients and their safety are still unknown. Al...
Chirality-Dependent Interaction of d- and l-Menthol with Biomembrane Models.
Chirality plays a vital role in biological membranes and has a significant effect depending on the type and arrangement of the isomer. Menthol has two typical chiral forms, d- and l-, which exhibit di...
Although epidemiological data and results from rodent studies support an inverse relationship between nicotine consumption and body weight, the molecular mechanisms are poorly understood. CD-1 mice we...
Medical and Biotech [MESH] Definitions
Lethal Dose 50
The dose amount of poisonous or toxic substance or dose of ionizing radiation required to kill 50% of the tested population.
Dose Hypofractionation
A treatment schedule in which the total dose of radiation is divided into large doses.
Menthol
An alcohol produced from mint oils or prepared synthetically.
Mice, Inbred Sencar
Mice selectively bred for hypersusceptibility to two-stage chemical skin carcinogenesis. They are also hypersusceptible to UV radiation tumorigenesis with single high-dose, but not chronic low-dose, exposures. SENCAR (SENsitive to CARcinogenesis) mice are used in research as an animal model for tumor production.
Maximum Tolerated Dose
The highest dose of a biologically active agent given during a chronic study that will not reduce longevity from effects other than carcinogenicity. (from Lewis Dictionary of Toxicology, 1st ed)
