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The purpose of this study is to find out how the provocation of the nose changes breathing style (specifically, frequency and tidal volume changes)
It is intended to clarify on both healthy and birch pollen allergic adults how the provocation of the nose with the birch pollen, dilutant and xylometazoline affect the breathing style (breathing pattern) and how these possible changes could be controlled in the measurement of the breathing with respiratory effort belts. In addition to this, our intention is to clarify the effect of the facial mask on the breathing.
The allergic and control subjects undergo nasal provocation in 2 sessions. The first is done with birch pollen extract (should block the nose in allergic subjects) and the second with xylometazoline (should open the nose).
The mask group undergo similar measurements without nasal exposures.
The second objective of the study is to clarify if there are differences between the allergic and control subjects in the function of the autonomous nervous system during these provocations. This is done with the heart rate variability analysis method.
Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Diagnostic
Birch Pollen Allergy
1. session birch pollen nasal exposure 2. session xylometazoline nasal exposure
Oulu University hospital, dept of Otorhinolaryngology
Not yet recruiting
Oulu University Hospital
Published on BioPortfolio: 2014-08-27T04:00:54-0400
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