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The Impact of Storage Techniques on Platelets Number and Function After Acute Normovolemic Hemodilution (ANH)

2014-09-25 15:08:22 | BioPortfolio

Summary

Acute normovolemic hemodilution (ANH) is part of our current protocol to decrease post-operative bleeding and homologous blood transfusions post cardiopulmonary bypass. Blood is drawn from our patients pre-bypass after obtaining the arterial line and administered back to the patient after separation from cardiopulmonary bypass (CPB) and reversal of heparin with protamine. In our practice we noticed some variability in the impact of ANH on postoperative bleeding; with some patients appearing to show more hemostasis after separation from CPB than others. This is a prospective study to find out if there is an optimal time period that guarantees the largest amount of functioning platelets and what is the best practice for drawing and storing of ANH to guarantee the largest amount of functioning platelets.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective

Conditions

Cardiac Surgical Procedures

Intervention

Acute normovolemic hemodilution (ANH)

Location

Nationwide Children's Hospital
Columbus
Ohio
United States
43205

Status

Enrolling by invitation

Source

Nationwide Children's Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-09-25T15:08:22-0400

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Medical and Biotech [MESH] Definitions

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).

Surgical procedures performed using a computer that remotely controls surgical instruments attached to mechanical arms designed to perform the tasks of the surgeon.

Surgery performed on the heart.

Procedures in which placement of CARDIAC CATHETERS is performed for therapeutic or diagnostic procedures.

Surgical procedures done to prevent or reduce the risk of developing cancer or other disease conditions in persons who may be predisposed to such conditions.

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