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A Study to Assess the Effect of Ketoconazole on the Metabolism of ABT-199

2014-10-23 21:23:22 | BioPortfolio

Summary

This is an open-label multicenter, study to assess the pharmacokinetic interaction of ketoconazole with ABT-199 in up to 12 subjects with relapsed or refractory non-Hodgkin's lymphoma.

Description

This is a Phase 1 study designed to assess how the body processes the study drug ABT-199 when taken alone and in combination with ketoconazole and to assess the safety of ABT-199 in combination with ketoconazole. Subjects may enroll in a separate extension study to continue receiving ABT-199 after completion of this study.

Study Design

Endpoint Classification: Pharmacokinetics Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Conditions

Non-Hodgkin's Lymphoma

Intervention

ABT-199, Ketoconazole

Location

Site Reference ID/Investigator# 101415
Hackensack
New Jersey
United States
07601

Status

Completed

Source

AbbVie

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-10-23T21:23:22-0400

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