Effects of Anesthesia on Pediatric Surgical Patients With a History of Concussion - Phase I

2014-11-06 00:53:22 | BioPortfolio


The purpose of this research study is to determine the number of children who have symptoms of a concussion at the time they are scheduled for orthopedic surgery at Boston Children's Hospital. It is currently unknown if anesthesia affects a child with a previously diagnosed concussion. This study is the first phase of a two-part study looking at the effects of anesthesia in children undergoing orthopedic surgery with a previous concussion. Currently, the decision to continue with surgery in patients with a diagnosed concussion is based on clinical judgment by the patients.


Phase I's specific aim is to estimate the incidence of symptomatic concussion in the pediatric orthopedic surgical population.

The first phase of this study requires a member of the research team to administer a paper questionnaire to all eligible, consented orthopedic surgery patients in either the Pre-operative Clinic or in the Day Surgery Unit over a period of four months. The research member will only approach adolescents that are scheduled for repair of orthopedic traumatic injury as defined in the inclusion criteria. The questionnaire is specifically designed to elicit occurrence and symptoms of a concussion. If the patient answers yes to question 2a, which asks "At the time of the injury do you recall a blow to the head, neck, face or body that resulted in sustained symptoms of concussion (e.g., headache, dizziness, confusion, nausea, vomiting, etc.)?", the research team will administer the 22 item self-reporting symptom scale in the above mentioned SCAT3. The responses obtained from the questionnaire will be used to determine the incidence of symptomatic concussions, either known or unrecognized, in pediatric patients sustaining an orthopedic injury requiring surgical repair. If the participant scores higher than a 0 on the SCAT3 the results will be conveyed to the surgeon prior to the start of the scheduled surgical procedure. A copy of the completed SCAT3 will also be placed in the medical record. The decision to continue with surgery and need to possibly refer the patient to the Boston Children's Hospital Sports Concussion Clinic after the SCAT3 will remain at the surgeon's discretion.

Information will be gathered from the questionnaire and the SCAT3, then entered into the REDcap database under a de-identified subject number.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Screening


Post Concussion Symptoms


Concussion Questionnaire


Boston Children's Hospital
United States




Children's Hospital Boston

Results (where available)

View Results


Published on BioPortfolio: 2014-11-06T00:53:22-0500

Clinical Trials [950 Associated Clinical Trials listed on BioPortfolio]

Vitamin Therapy in Concussion Management: A Randomized Control Trial

The purpose of this study is to assess the efficacy of vitamin therapy in concussion when compared to placebo with respect to multiple endpoints including symptom severity, cognitive perfo...

Evaluation of a Physical Intervention for Persistent Post-Concussive Symptoms

A concussion occurs when a person receives an impact to the head. The most common persistent symptoms that generate from a concussion are headaches, depression, lack of balance and dizzine...

Longitudinal Study of Children With Concussions

For children and adolescents who have had a concussion resulting in prolonged symptoms (>3 months), the investigators will: 1. Measure post-concussion symptoms, cognitive and emotional ...

A Sports Injury Prevention Program to Reduce Subsequent Injuries After Concussion

The long-term goal of this research is to implement methods that healthcare providers can use across diverse clinical settings to (1) identify athletes at risk for (musculoskeletal) MSK in...

Trial of Aerobic Treadmill Exercise Treatment for Concussion

A post-concussion syndrome (PCS) diagnosis has historically led to a recommendation of continued mental and physical rest to minimize symptoms. However, this conservative approach does not...

PubMed Articles [10755 Associated PubMed Articles listed on BioPortfolio]

Review of the Management of Pediatric Post-Concussion Syndrome-a Multi-Disciplinary, Individualized Approach.

Post-concussion syndrome (PCS), when the patient's concussion symptoms last longer than 4-6 weeks, affects 10-30% of concussion patients. PCS presents a significant source of morbidity to patients an...

Neurophysiological Abnormalities in Individuals with Persistent Post-Concussion Symptoms.

Concussion injury results in a rapid onset of transient neurological impairment that can resolve quickly, or sometimes evolve over time, but usually resolve within seven to ten days. However, a small ...

Concussion in Children.

Concussions are common in pediatric athletes, but they often go underreported. The topic of concussions has garnered much attention from the media recently, and this attention has resulted in the deve...

The Role of Aerobic Exercise in Reducing Persistent Sport-related Concussion Symptoms.

Aerobic exercise has received increasing attention in the scientific literature as a component of management for individuals who sustain a concussion. Since exercise training has been reported to redu...

Psychological Resilience as a Predictor of Symptom Severity in Adolescents With Poor Recovery Following Concussion.

Examine the mediating effects of anxiety and depressive symptoms on the relationship between psychological resilience and post-concussive symptoms (PCS) in children with poor recovery following concus...

Medical and Biotech [MESH] Definitions

The organic and psychogenic disturbances observed after closed head injuries (HEAD INJURIES, CLOSED). Post-concussion syndrome includes subjective physical complaints (i.e. headache, dizziness), cognitive, emotional, and behavioral changes. These disturbances can be chronic, permanent, or late emerging.

A nonspecific term used to describe transient alterations or loss of consciousness following closed head injuries. The duration of UNCONSCIOUSNESS generally lasts a few seconds, but may persist for several hours. Concussions may be classified as mild, intermediate, and severe. Prolonged periods of unconsciousness (often defined as greater than 6 hours in duration) may be referred to as post-traumatic coma (COMA, POST-HEAD INJURY). (From Rowland, Merritt's Textbook of Neurology, 9th ed, p418)

Injuries resulting when a person is struck by particles impelled with violent force from an explosion. Blast causes pulmonary concussion and hemorrhage, laceration of other thoracic and abdominal viscera, ruptured ear drums, and minor effects in the central nervous system. (From Dorland, 27th ed)

A class of traumatic stress disorders with symptoms that last more than one month. There are various forms of post-traumatic stress disorder, depending on the time of onset and the duration of these stress symptoms. In the acute form, the duration of the symptoms is between 1 to 3 months. In the chronic form, symptoms last more than 3 months. With delayed onset, symptoms develop more than 6 months after the traumatic event.

Self report questionnaire which yields 16 scores on personality traits, such as reserved vs. outgoing, humble vs. assertive, etc.

More From BioPortfolio on "Effects of Anesthesia on Pediatric Surgical Patients With a History of Concussion - Phase I"

Quick Search


Relevant Topics

Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...

Arthroplasty Joint Disorders Orthopedics Spinal Cord Disorders Orthopedics is the science or practice of correcting deformities caused by disease or damage to the bones and joints of the skeleton. This specialized branch of surgery may ...

Surgical treatments
Surgery is a technology consisting of a physical intervention on tissues. All forms of surgery are considered invasive procedures; so-called "noninvasive surgery" usually refers to an excision that does not penetrate the structure being exci...

Searches Linking to this Trial