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The purpose of this study is increase the efficacy of consolidation (C1) after an intensification phase with high dose of methotrexate, applying analysis of minimal residual disease
- 60 mg/m2 day, i.v. or p.o., days 1 to 27
- 30 mg/m2 day, i.v. or p.o., days 28 to 35
Vincristine (VCR): 1,5 mg/m2 i.v., days 8, 15, 22 and 28. Daunorubicin (DNR): 30 mg/m2, i.v., days 8 and 15. L-asparaginase (L-ASA): 10.000 UI/m2, i.m. or i.v., days 9 to 11, 16 to 18 and 23 to 25.
Cyclophosphamide (CFM): 1000 mg/m2, i.v., day 22.
Methotrexate (MTX), cytosine (ARA-C) and hydrocortisone, days 1 and 22
CONSOLIDATION TREATMENT (WEEKS 6 TO 14)with INTENSIFICACIÓN (C-1)
- Mercaptopurine (MP) 50 mg/m2, p.o., days 1-7, 28-35 and 56-63
- MTX: 3g/m2, i.v., in 24 hours, days 1, 28 and 56.
- VP-16: 150 mg/m2 i.v., days 14-15 and 42-43
- ARA-C: 1000 mg/m2 i.v., in 3 hours, days 14-15 and 42-43
- Intrathecal treatment, days 1, 28 and 56.
REINDUCTION-CONSOLIDATION TREATMENT (R-C) (WEEKS 15 TO 23)
- 6 mg/m2 day, p.o., days 1-21
- 3 mg/m2 day, p.o. or i.v., days 22-28 VCR: 1,5 mg/m2, i.v., days 1, 8 and 15 DNR: 30 mg/m2, i.v., days 1 and 8 L-ASA: 10.000 UI/m2 i.m. or i.v., days 8 and 9, 15 and 16, 22 and 23. CFM 1000 mg/m2 day, i.v., day 22 Mercaptopurine (MP) 50 mg/m2, p.o., days 35-42 MTX: 3g/m2, i.v., in 24 hours, day 35. VP-16: 150 mg/m2 i.v., days 49-50 ARA-C: 1.000 mg/m2 i.v., in 3 hours, days 49-50 Intrathecal treatment days 1 and 35.
MAINTENANCE TREATMENT (M-1)
- MP 50 mg/m2/day, p.o.
- MTX 20 mg/m2/week, i.m.
- VCR: 1,5 mg/m2 i.v., day 1.
- PDN: 30 mg/m2/day, i.v. or p.o., days 1 to 7
- L-ASA: 20.000 UI/m2, i.m. or i.v., day 1.
- Intrathecal treatment day 1 Five cycles, weeks 24, 30, 36, 42 and 48. During the week of administration cycle, continuous chemotherapy should be suspended.
Intrathecal treatment: At the start of any reinduction cycle
MAINTENANCE TREATMENT (M-2) (WEEKS 55-108)
- MP 50 mg/m2/day, p.o.
- MTX 20 mg/m2/week, i.m.
- Intrathecal treatment, weeks 54 and 108
At the end of treatment should be done the study of MRD (flux cytometry)
Allocation: Non-Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment
Acute Lymphoblastic Leukemia
Prednisone, Vincristine, Daunorubicin, L-Asparaginase, Cyclophosphamide, Methotrexate, Cytosine Arabinoside, Mercaptopurine, VP-16
. Hospital Clínico Universitario Virgen de la Victoria
Published on BioPortfolio: 2014-11-13T03:23:23-0500
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An enzyme that catalyzes reversibly the phosphorylation of deoxycytidine with the formation of a nucleoside diphosphate and deoxycytidine monophosphate. Cytosine arabinoside can also act as an acceptor. All natural nucleoside triphosphates, except deoxycytidine triphosphate, can act as donors. The enzyme is induced by some viruses, particularly the herpes simplex virus (HERPESVIRUS HOMINIS). EC 126.96.36.199.
Precursor of an alkylating nitrogen mustard antineoplastic and immunosuppressive agent that must be activated in the LIVER to form the active aldophosphamide. It has been used in the treatment of LYMPHOMA and LEUKEMIA. Its side effect, ALOPECIA, has been used for defleecing sheep. Cyclophosphamide may also cause sterility, birth defects, mutations, and cancer.
An enzyme that catalyzes the transfer of a methyl group from S-ADENOSYLMETHIONINE to the 5-position of CYTOSINE residues in DNA.
Enzymes that catalyzes the transfer of a methyl group from S-ADENOSYLMETHIONINE to the 5-position of CYTOSINE residues in DNA.
An enzyme which catalyzes the deamination of CYTOSINE resulting in the formation of URACIL. It can also act on 5-methylcytosine to form THYMIDINE.
Leukemia is a type of cancer of the blood or bone marrow characterized by an abnormal increase of immature white blood cells called "blasts". Leukemia is a broad term covering a spectrum of diseases. In turn, it is part of the even broader grou...