HO-1 and Muscle Mitochondrial Dysfunction in Sepsis

2015-02-16 21:18:11 | BioPortfolio


The current project was designed to examine dynamic changes in muscle wasting during sepsis. Researchers will focus the mitochondrial dysfunction of muscle cells and investigate the role of HO-1 in it. Researchers interested in identifying factors involved in the pathology of muscle wasting during sepsis.


Rapid muscle atrophy or muscle wasting occured to septic patients.Sepsis induced muscle wasting has become a severe, frequent, and persistent complication among critically ill patients. Multiple factors including ubiquitin-proteasome system, proinflammatory cytokines and oxidative stress contribute muscle proteolysis.

It is known that heme oxygenase-1 (HO-1) possesses a variety of functions like anti-inflammatory, antioxidative and anti-apoptosis effects. In order to investigate the mechanisms under the condition, researchers are going to examine the role of HO-1 in muscle atrophy during sepsis.

Study Design

Observational Model: Case Control, Time Perspective: Prospective




therapy according to SSC guidelines and muscle biopsy, standard surgery for femoral fracture and muscle biopsy


Anesthesiology and Intensive Care, Changhai Hospital


Active, not recruiting


Changhai Hospital

Results (where available)

View Results


Published on BioPortfolio: 2015-02-16T21:18:11-0500

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