Advertisement

Topics

Gluten-free Diet Monitoring in Urine

2015-02-19 22:38:22 | BioPortfolio

Summary

The purpose of this study is to develope a novel method to determine gluten intake and to check gluten-free diet adherence in celiac patients by detection of gluten immunogenic peptides in urine.

Description

To date, the mainstay of the management of CD is a strict life-long adherence to gluten-free diet (GFD). Follow-up monitoring of the improvement of patients on GFD is essential to assess symptomatic recovery and to monitor complications, as well as to assist patients with dietary compliance. However, practical methods to monitor diet compliance and to detect the origin of an outbreak of celiac clinical symptoms are not available.

In this study, we have overcome these challenges and shown the feasibility of measuring gluten immunogenic peptides (GIP) in urine samples in healthy and celiac individuals by solid phase extraction and estimating the peptide concentrations with a reader of anti-GIP moAb immunochromatographic strips (IC-strips).

Study Design

Allocation: Randomized, Intervention Model: Parallel Assignment

Conditions

Celiac Disease

Intervention

Non-invasive lateral flow test for monitoring gluten intake, gluten-free diet (GFD), gluten-containing diet

Location

Department of Microbiology and Parasitology, Faculty of Pharmacy, University of Seville
Seville
Spain
41012

Status

Completed

Source

University of Seville

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-02-19T22:38:22-0500

Clinical Trials [3057 Associated Clinical Trials listed on BioPortfolio]

Effect of Gluten-free Diets on Anthropometric and Dietary Data of Healthy Eutrophic Women

The objective is to evaluate, in healthy, eutrophic women, if gluten intake influences on body weight, basal metabolic rate and macronutrient intake. In a crossover double masked model, 30...

Change in Permeability of the Small Intestine After Treatment

The overall hypothesis of this research study is that gluten intake alters intestinal barrier function in patients with Irritable Bowel Syndrome (IBS) diarrhea who also exhibit non-celiac ...

Effects of Home Gluten Immunogenic Peptide Testing on Children With Celiac Disease

This study aims to investigate how knowledge of gluten immunogenic peptide (GIP) levels in stool and urine affects subsequent adherence to a gluten-free diet. Half of the participants will...

Gluten Sensibility in Elite Athletes

This clinical project aims to study the relationship between gluten consumption and its impact on digestive comfort, quality of life and performance of non-celiac athletes practicing an in...

Dietary Triggers of Gastrointestinal Symptoms in IBS Patients

This crossover randomized controlled trial will evaluate the effects of gluten and gluten combined with amylase-trypsin inhibitors (ATIs) on inducing intestinal and extra-intestinal sympto...

PubMed Articles [17658 Associated PubMed Articles listed on BioPortfolio]

Rapid and selective luminescent sensing of allergenic gluten by highly phosphorescent switch-on probe.

First time the luminescent switch-on probe using novel water-soluble cyclometallated iridium complex (Ir-dc) has been developed for sensitive and selective detection of gluten in the presence of sever...

Impact of sodium citrate on structural properties of gluten.

The effect of sodium citrate on gluten-starch separation and physicochemical properties of gluten was studied. The results showed that the addition of sodium citrate to the dough caused to an improvem...

Cross-Contamination with Gluten by Using Kitchen Utensils: Fact or Fiction?

A risk of cross-contamination exists when preparing a gluten-free (GF) meal in kitchen facilities that usually handle gluten-containing (GC) foods. Cross-contamination with gluten may occur during the...

Too picky for my taste? The effect of the gluten-free dietary restriction on impressions of romantic partners.

Millions of individuals world-wide adhere to a gluten-free diet and this dietary trend is on the rise. The present research identified a consumption stereotype of those following a gluten-free diet an...

Gluten-Free Products for Celiac Susceptible People.

The gluten protein of wheat triggers an immunological reaction in some gluten-sensitive people with HLA-DQ2/8 genotypes, which leads to Celiac disease (CD) with symptomatic damage in the small intesti...

Medical and Biotech [MESH] Definitions

A diet which is devoid of GLUTENS from WHEAT; BARLEY; RYE; and other wheat-related varieties. The diet is designed to reduce exposure to those proteins in gluten that trigger INFLAMMATION of the small intestinal mucosa in patients with CELIAC DISEASE.

Simple protein, one of the prolamines, derived from the gluten of wheat, rye, etc. May be separated into 4 discrete electrophoretic fractions. It is the toxic factor associated with CELIAC DISEASE.

A malabsorption syndrome that is precipitated by the ingestion of GLUTEN-containing foods, such as wheat, rye, and barley. It is characterized by INFLAMMATION of the SMALL INTESTINE, loss of MICROVILLI structure, failed INTESTINAL ABSORPTION, and MALNUTRITION.

A malabsorption syndrome characterized by collagenous mucosal lesions of the SMALL INTESTINE, atrophy of MICROVILLI, severe malabsorption, diarrhea, and MALNUTRITION often refractory to a gluten-free diet.

A test to determine the ability of an individual to maintain HOMEOSTASIS of BLOOD GLUCOSE. It includes measuring blood glucose levels in a fasting state, and at prescribed intervals before and after oral glucose intake (75 or 100 g) or intravenous infusion (0.5 g/kg).

More From BioPortfolio on "Gluten-free Diet Monitoring in Urine"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Celiac Disease
Celiac disease is a digestive disease that damages the small intestine and interferes with absorption of nutrients from food. People who have celiac disease cannot tolerate gluten, a protein in wheat, rye, and barley. Gluten is found mainly in foods but ...

Urology
Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...


Searches Linking to this Trial