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Mechanistic Studies of Phase III Trial With BAF312 in Secondary Progressive Multiple Sclerosis

2015-03-12 02:23:26 | BioPortfolio

Summary

The primary goal of this study is to evaluate the effects of BAF312 (siponimod) on select immune and neuronal (nerve) cells by examining laboratory specimens (blood and/or spinal fluid) at multiple time points, prior to, and following the initiation of BAF312 or placebo treatment, in patients with Secondary Progressive Multiple Sclerosis (SPMS) who are enrolled in a clinical trial (NCT01665144) to evaluate the effectiveness and safety of BAF312.

Description

This study is complementary to a multi-center, randomized, double-blind,parallel-group, placebo-controlled, variable treatment duration study comparing the efficacy and safety of BAF312 to placebo in patients with SPMS (NCT01665144). Investigators will explore both immunological and neuroprotective mechanisms of BAF312 (siponimod), a novel agent in the setting of a SPMS clinical trial.

This study is part of a multi-center study, with the University of Michigan serving as the central site.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Secondary Progressive Multiple Sclerosis

Intervention

Blood Draw, CSF collection by lumbar puncture (Optional)

Location

HOPE Research Institute
Phoenix
Arizona
United States
85032

Status

Recruiting

Source

National Institute of Allergy and Infectious Diseases (NIAID)

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-03-12T02:23:26-0400

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