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Genitourinary and Pharyngeal Pharmacokinetics of Solithromycin

2015-03-25 05:24:23 | BioPortfolio

Published on BioPortfolio: 2015-03-25T05:24:23-0400

Clinical Trials [15 Associated Clinical Trials listed on BioPortfolio]

Rapid Diagnosis of Antibiotic Resistance in Gonorrhoea

The purpose of this study is to develop a laboratory-based assay that will be a real-time PCR test to detect the organism N. gonorrhoeae and its most important genetic markers of antimicro...

A Study to Evaluate the Anti-inflammatory Effects of Solithromycin in Chronic Obstructive Pulmonary Disease

This study examines the potential benefit of a new antibiotic, Solithromycin, for the long-term treatment of Chronic Obstructive Pulmonary Disease (COPD). Solithromycin is hypothesised to ...

Pharmacokinetics and Safety of Solithromycin in Adolescents and Children

Pediatric study to evaluate the safety and pharmacokinetics of solithromycin (oral and intravenous) in children ages 0 to 17

Safety and Efficacy of Solithromycin in the Treatment of Nonalcoholic Steatohepatitis Without Cirrhosis

The purpose of this study is to evaluate the effects of solithromycin on hepatic histology and biomarkers in patients with nonalcoholic steatohepatitis.

A Study to Evaluate the Efficacy and Safety of Oral Solithromycin Compared to Intramuscular Ceftriaxone Plus Oral Azithromycin in the Treatment of Patients With Gonorrhea

This study will compare a single dose of oral solithromycin to the standard of care (intramuscular ceftriaxone plus oral azithromycin) in the treatment of patients with urogenital gonorrhe...

PubMed Articles [13 Associated PubMed Articles listed on BioPortfolio]

Overcoming the Challenges of Low Drug Solubility in the Intravenous Formulation of Solithromycin.

Solithromycin is a fluoro-ketolide (a fourth-generation macrolide) antibiotic that has been undergoing clinical trials for the treatment of community acquired bacterial pneumonia. In this study, devel...

Epidemiological, behavioural, and clinical factors associated with antimicrobial-resistant gonorrhoea: a review.

Antimicrobial-resistant is a global public health problem in the 21st century. has developed resistance to all classes of antibiotics used for empirical treatment, and clinical treatment failure cau...

Spatial clusters of gonorrhoea in England with particular reference to the outcome of partner notification: 2012 and 2013.

This study explored spatial-temporal variation in diagnoses of gonorrhoea to identify and quantify endemic areas and clusters in relation to patient characteristics and outcomes of partner notificatio...

Genomic epidemiology and antimicrobial resistance of Neisseria gonorrhoeae in New Zealand.

Antimicrobial-resistant Neisseria gonorrhoeae is a major threat to public health. No studies to date have examined the genomic epidemiology of gonorrhoea in the Western Pacific Region, where the incid...

The Effect of Solithromycin, a Cationic Amphiphilic Drug, on the Proliferation and Differentiation of Human Meibomian Gland Epithelial Cells.

We previously discovered that azithromycin (AZM) acts directly on immortalized human meibomian gland epithelial cells (IHMGECs) to stimulate their lipid and lysosome accumulation and overall different...

Medical and Biotech [MESH] Definitions

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