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Using Serum Parathyroid Hormones and Calcium to Improve Prostate Cancer Diagnosis

2015-04-15 11:08:22 | BioPortfolio

Summary

This is a cross sectional study to examine the relationship between serum calcium and PTHrP and serum PSA in men referred for prostate biopsy at Wake Forest University.

Description

This is a cross sectional study to examine the relationship between serum calcium and PTHrP and serum PSA in men referred for prostate biopsy at Wake Forest University. Men scheduled for biopsy will be approached by the study nurse who will explain the study and invite the men to participate. After the patients provide written consent, she/he will obtain the following information from the patient chart: age, race (self-report, white, black, other), height, weight (for determination of Body Mass Index, a variable reported to influence PSA). Blood draw for study analytes will be coordinated with routine blood draw for PSA testing to minimize the need for an additional needle stick. A copy of the informed consent is given to the patient and the original is placed in a file for the P.I.

The biopsy status of men at the time they are invited to participate is unknown. Men are "sorted" into cancer and non-cancer groups only after their biopsies are read. Serum samples are sent to the Department of Laboratory Medicine at Wake Forest. All assays are performed "in house". Based on consultation with our urologists, we anticipate that approximately 30% of the biopsies will be positive (i.e., prostate cancer). The majority (approximately 70%) will be negative (benign). Approximately 1-2% of the biopsies may be classified as "indeterminate". Because there will not be a sufficient number of "indeterminate" pathologies to be treated as a separate category, this group will not be analyzed further. However, men with "indeterminate" biopsies are eligible for the study if they are re-biopsied.

Study Design

Observational Model: Cohort, Time Perspective: Prospective

Conditions

Prostate Cancer

Intervention

This study has no intervention

Location

Comprehensive Cancer Center of Wake Forset University
Winston-Salem
North Carolina
United States
27157

Status

Recruiting

Source

Comprehensive Cancer Center of Wake Forest University

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-04-15T11:08:22-0400

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