Advertisement

Topics

Treatment for Nicotine Addiction in Women

2015-05-21 21:23:25 | BioPortfolio

Summary

The purpose of this study is to use a medication tolcapone and or placebo to test if the symptoms of nicotine withdrawal lessens , and or changes in smoking urges, and mental reasoning in female smokers over a 72 hour period.

Description

The proposed trail will be use a double-blind, placebo-controlled design to conduct the first randomized controlled trial of the COMT inhibitor, tolcapone, in nicotine dependent women. This study will determine if tolcapone is superior to placebo by attenuation the severity of nicotine withdrawal and smoking urges during short-term abstinence. Withdrawal severity will be assessed by a self-report scale and cognitive assessment, including a sustained-attention task. Smoking urges will be assessed by a self-report scale.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Nicotine Dependence

Intervention

Tolcapone, Sugar Pill

Status

Not yet recruiting

Source

Yale University

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-05-21T21:23:25-0400

Clinical Trials [1225 Associated Clinical Trials listed on BioPortfolio]

Evaluate the Effects of Tolcapone on Cognitive and Behavioral Dysfunction in Patients With TBI and MCI

The experimental design is an open-label two-week trial of tolcapone to evaluate which clinical domains are affected by tolcapone treatment and to identify "responders" to tolcapone treatm...

Testing a Full Substitution Therapy Approach As Treatment of Tobacco Dependence

This study will test a new medication strategy designed to help smokers quit. It will combine selegiline, a drug currently approved and available for the treatment of Parkinson's disease, ...

A Study Assessing the Safety and Pharmacokinetic Profile of Modified Release Formulations of Tolcapone

The purpose of this study is to assess the pharmacokinetic profiles of tolcapone in healthy subjects after administration of one or two oral doses of multiple modified release prototype fo...

An Effectiveness Trial of Maintenance Therapy for Nicotine Dependence

The transdermal nicotine patch is the most widely used form of tobacco dependence treatment in the US and Europe, but most smokers are unable to successfully quit with this form of treatme...

Neural Substrates in Nicotine Withdrawal

This study will test the hypothesis that a medication called tolcapone (Brand Name: Tasmar) will help reduce cognitive problems that smokers experience when they quit. This study will als...

PubMed Articles [2440 Associated PubMed Articles listed on BioPortfolio]

Assessing nicotine dependence in adolescent E-cigarette users: The 4-item Patient-Reported Outcomes Measurement Information System (PROMIS) Nicotine Dependence Item Bank for electronic cigarettes.

Adolescent e-cigarette use (i.e., "vaping") likely confers risk for developing nicotine dependence. However, there have been no studies assessing e-cigarette nicotine dependence in youth. We evaluated...

Nicotine dependence among adolescents in the European Union: How many and who are affected?

Nicotine dependence during adolescence increases the risk of continuing smoking into adulthood. The magnitude of nicotine dependence among adolescents in the European Union (EU) has not been establish...

E-cigarette- specific symptoms of nicotine dependence among Texas adolescents.

The potential of e-cigarettes to elicit symptoms of nicotine dependence has not been adequately studied, particularly in adolescent populations. The present study examined the prevalence of e-cigarett...

METABOLISM AND ELIMINATION OF THE CATECHOL-O-METHYLTRANSFERASE INHIBITOR TOLCAPONE IN THE HORSE.

The metabolism of the masking agent tolcapone in the horse has been investigated. This substance was found to have undergone various chemical transformations that produced a large variety of phase I m...

Correlates of nicotine dependence in men with childhood attention-deficit/hyperactivity disorder: a 33-year follow-up.

Identify correlates of nicotine dependence [lifetime (l) and ongoing (o)] in adults with attention-deficit/hyperactivity disorder (ADHD) in childhood. We conducted a 33-year prospective follow-up of b...

Medical and Biotech [MESH] Definitions

Nicotine is highly toxic alkaloid. It is the prototypical agonist at nicotinic cholinergic receptors where it dramatically stimulates neurons and ultimately blocks synaptic transmission. Nicotine is also important medically because of its presence in tobacco smoke.

Chewing gum which contains NICOTINE.

Strong dependence, both physiological and emotional, upon morphine.

Strong dependence, both physiological and emotional, upon heroin.

Strong physiological and emotional dependence on OPIUM.

More From BioPortfolio on "Treatment for Nicotine Addiction in Women"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Pharmacy
Pharmacy is the science and technique of preparing as well as dispensing drugs and medicines. It is a health profession that links health sciences with chemical sciences and aims to ensure the safe and effective use of pharmaceutical drugs. The scope of...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...


Searches Linking to this Trial