Sutent Rechallenge In mRCC Patients

2015-05-21 21:23:26 | BioPortfolio


Retrospective and prospective study in mRCC patients treated with sutent in first line and rechallenged by Sutent in 3rd and 4th line.


A sample size of n = 40 patients will allow to estimate of the median PFS with a precision around 1.8 months (based on data from Rini et al.) This retrospective and prospective study is designed to estimate the effect of Sutent rechallenge.

The PFS (estimated from Kaplan-Meier estimate) will be the primary endpoints. In addition, the effects of sunitinib at the 2 periods of treatment (i.e. first line sunitinib vs. rechallenge) will be compared by Wilcoxon signed-rank test for PFS values and by McNemar test for overall response rate (ORR).

Study Design

Observational Model: Cohort, Time Perspective: Retrospective


Metastatic Renal Cell Carcinoma


sunitinib: observational study


CHU de la Timone
Cedex 5





Results (where available)

View Results


Published on BioPortfolio: 2015-05-21T21:23:26-0400

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