Track topics on Twitter Track topics that are important to you
The goal of this research study is to understand the relationship between the hormone oxytocin and postpartum mood. Based on previous research, the investigators hypothesize that lower plasma oxytocin concentration during pregnancy will predict a greater likelihood of postpartum depression. Second, it is expected that oxytocin concentration in the third trimester will show an inverse relationship with the severity of depressive symptoms at 4 - 6 weeks postpartum.
Potential participants in the study will be screened for eligibility during their third trimester of pregnancy, using a combination of questionnaires. Those who are eligible for participation will have one blood sample drawn at this time, and then be asked to complete a follow up questionnaire at 4-6 weeks postpartum to assess for depressive mood symptoms. This follow up questionnaire can be completed either in person or on the telephone. Anyone who is interested in receiving help for their mood at any point in the study will receive referrals.
Postpartum depression affects some one in five new mothers, and adversely influences maternal adaptation to motherhood. While it is known that women with a prior history of depression, or depression during pregnancy, are at elevated risk for postpartum depression, many women with no prior history of depression or other risk factors go on to develop depression in the postpartum period. Considering the grave consequences of postpartum depression on maternal infant bonding and childhood psychological development, it is critical to develop reliable methods to identify which women, who are not depressed during pregnancy, will become depressed after delivery.
The biological pathways leading to depression at any time in life, including around pregnancy, are still poorly characterized. Oxytocin, a hormone involved in delivery and lactation, has received recent attention regarding its additional role in maternal emotions and care taking behaviors after birth. Specifically, lower plasma oxytocin concentration in the third trimester of pregnancy has been linked to an increased risk of depression at two weeks postpartum (Skrundz et al., 2001).
The primary goal of this study is to replicate previous findings and clarify whether oxytocin is predictive of clinically significant depression at 4 - 6 weeks postpartum, using a more comprehensive diagnostic measure for depression.
Observational Model: Cohort, Time Perspective: Prospective
Northwestern Memorial Hospital
Active, not recruiting
Published on BioPortfolio: 2015-06-09T01:38:23-0400
This study will determine whether a prevention program reduces the incidence of postpartum depression in pregnant women who receive public assistance and are at risk for postpartum depress...
The purpose of this study is to examine the feasibility and efficacy of an exercise intervention for the prevention of postpartum depression. If efficacious, our intervention could be dis...
Postpartum depression (PPD) affects approximately 15% of women during the first year after giving birth, and is common across cultures. The etiology of postpartum depression is not totally...
Through a recent cross species translational experiment, researchers have identified a set of epigenetic marks capable of predicting postpartum depression with greater than 85% accuracy. T...
Postpartum depression is common in mothers early after childbirth and produces harmful effects not only on mothers, but also on infants and young children. Parturietns with prenatal depres...
Postpartum depression is an important cause of morbidity in mothers and children. The Edinburgh Postpartum Depression Scale (EPDS), the most widely used self-reported measure of postpartum depression,...
Although prenatal depression is a risk factor for postpartum depression, current screening tools for prenatal depression fail to predict postpartum depression in some marginalized populations.
Out of the various risk factors for postpartum depression, use of pharmacotherapy during pregnancy is the most poorly understood. The present study aimed to establish risk of postpartum depression and...
to evaluate breastfeeding self-efficacy, the presence of postpartum depression symptons and the association between breastfeeding self-efficacy and postpartum depression with cessation of exclusive br...
This study was conducted to determine the risk of postpartum depression in husbands of women who had a caesarean section and the factors affecting this risk. The study sample included husbands of 298 ...
Depression in POSTPARTUM WOMEN, usually within four weeks after giving birth (PARTURITION). The degree of depression ranges from mild transient depression to neurotic or psychotic depressive disorders. (From DSM-IV, p386)
Transient autoimmune thyroiditis occurring in the POSTPARTUM PERIOD. It is characterized by the presence of high titers of AUTOANTIBODIES against THYROID PEROXIDASE and THYROGLOBULIN. Clinical signs include the triphasic thyroid hormone pattern: beginning with THYROTOXICOSIS, followed with HYPOTHYROIDISM, then return to euthyroid state by 1 year postpartum.
Decompression external to the body, most often the slow lessening of external pressure on the whole body (especially in caisson workers, deep sea divers, and persons who ascend to great heights) to prevent DECOMPRESSION SICKNESS. It includes also sudden accidental decompression, but not surgical (local) decompression or decompression applied through body openings.
Excess blood loss from uterine bleeding associated with OBSTETRIC LABOR or CHILDBIRTH. It is defined as blood loss greater than 500 ml or of the amount that adversely affects the maternal physiology, such as BLOOD PRESSURE and HEMATOCRIT. Postpartum hemorrhage is divided into two categories, immediate (within first 24 hours after birth) or delayed (after 24 hours postpartum).
Depressive states usually of moderate intensity in contrast with major depression present in neurotic and psychotic disorders.
Diabetes Diabetes Endocrine Obesity Oxycontin Renal Disease Thyroid Disorders Endocrinology is the study of the endocrine glands and the hormones that they secrete (Oxford Medical Dictionary). There are several groups of h...
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells. In vertebrates, it is composed of blo...
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...