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Synovial Fluid Molecular and Stem Cell Response to Platelet Rich Plasma in Knee Osteoarthritis With Clinical and Imaging Outcome Correlation: Proof of Concept Study

2015-06-11 02:23:21 | BioPortfolio

Summary

The purpose of this study is to evaluate the affect that platelet rich plasma has on the molecular an cellular functioning of the knee joint.

Description

In this study 18 subjects with mild to moderate symptomatic knee osteoarthritis will be recruited per an IRB approved protocol with explicit inclusion and exclusion criteria. Subjects who are enrolled and meet all criteria will be blinded and randomized (2:1) to receive Platelet Rich Plasma or normal saline "control". Prior to the intervention, a synovial fluid aspiration will occur. At follow up number one (approximately 10 days from baseline) a repeat aspiration will occur and a differential analysis of the molecular and biochemical effects will be undertaken; this data will serve as the primary outcome measures. This data will be correlated to clinical and imaging outcome measures which will be secondary outcome measures completed at baseline and intermittently throughout the study. The duration of the study is one year.

Study Design

Allocation: Randomized, Endpoint Classification: Pharmacodynamics Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Subject), Primary Purpose: Basic Science

Conditions

Knee Osteoarthritis

Intervention

Platelet Rich Plasma, Normal Saline

Location

Hunter Holmes McGuire VA Medical Center
Richmond
Virginia
United States
23224

Status

Recruiting

Source

Hunter Holmes Mcguire Veteran Affairs Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-06-11T02:23:21-0400

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Medical and Biotech [MESH] Definitions

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A preparation consisting of PLATELETS concentrated in a limited volume of PLASMA. This is used in various surgical tissue regeneration procedures where the GROWTH FACTORS in the platelets enhance wound healing and regeneration.

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The preparation of platelet concentrates with the return of red cells and platelet-poor plasma to the donor.

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