To Study the Individual Variants of Chemotherapy-Induced Neurotoxicity

2015-06-26 06:23:23 | BioPortfolio


To study the risk prediction of chemotherapy-induced peripheral neuropathy (CIPN) by the clinical bioinformatics and genomic profile.


This is a prospective, observational, cohort study, monitoring the chemotherapy-induced peripheral neurotoxicity by traditional clinical scales, neurological examinations, and semi-quantitative assessments. Moreover, all the genetic changes will be analyzed by next generation sequencing and we will try to identify relevant variants in individuals who suffer from chemotherapy-induced neurotoxicity.

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Neurotoxicity Syndromes


Questionnaires, Peripheral nervous system examination, Whole Genome Sequence


National Cheng Kung University Hospital




National Cheng-Kung University Hospital

Results (where available)

View Results


Published on BioPortfolio: 2015-06-26T06:23:23-0400

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Medical and Biotech [MESH] Definitions

The nervous system outside of the brain and spinal cord. The peripheral nervous system has autonomic and somatic divisions. The autonomic nervous system includes the enteric, parasympathetic, and sympathetic subdivisions. The somatic nervous system includes the cranial and spinal nerves and their ganglia and the peripheral sensory receptors.

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Diseases of the central and peripheral nervous system. This includes disorders of the brain, spinal cord, cranial nerves, peripheral nerves, nerve roots, autonomic nervous system, neuromuscular junction, and muscle.

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