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The Effect of Sumatriptan and Placebo on Isosorbide-5-mononitrate Induced Headache

2015-07-01 07:23:22 | BioPortfolio

Summary

To develop a pragmatic migraine model the investigators will induce headache in healthy volunteers and in patients with migraine without aura with a long lasting NO donor. If the headache responds to sumatriptan, the model can be used to test new drug candidates.

Description

There remains a great need for more effective anti-migraine drugs with fewer side effects. Human experimental models are valuable in early phase development of new anti-migraine drugs but useful models have not yet been developed. The investigators' group has shown that Isosorbide-5-mononitrate (5-ISMN), a long lasting NO-donor, induce headache/migraine in both healthy volunteers and in patients with migraine without aura (MO). To validate this model, the headache must respond to specific migraine treatment with sumatriptan.

Hypothesis: 5-ISMN induces a migraine-like headache in both healthy subjects and in MO-patients and induced headache responds to a specific anti migraine drug; sumatriptan.

Aim: Developing a pragmatic and valid model for the testing of new anti-migraine drugs

Study Design

Allocation: Randomized, Intervention Model: Crossover Assignment, Masking: Double Blind (Subject, Investigator), Primary Purpose: Treatment

Conditions

Migraine

Intervention

5-ISMN (isosorbide-5-mononitrate), Sumatriptan, Placebo

Location

Emma Katrine Hansen
Copenhagen
Glostrup
Denmark
2600

Status

Recruiting

Source

Danish Headache Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-07-01T07:23:22-0400

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