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TIPS vs Endoscopic Therapy for Variceal Rebleeding in Cirrhotic Patients With Occlusive Portal Vein Thrombosis

2015-07-01 07:23:22 | BioPortfolio

Summary

Occlusive portal vein thrombosis may be a negative prognostic marker of variceal bleeding in liver cirrhosis. Compared with conventional endoscopic and pharmacological therapy, transjugular intrahepatic portosystemic shunt may further improve the outcomes of occlusive portal vein thrombosis in liver cirrhosis with variceal bleeding.

Description

Occlusive portal vein thrombosis may be a negative prognostic marker of variceal bleeding in liver cirrhosis. Compared with conventional endoscopic and pharmacological therapy, transjugular intrahepatic portosystemic shunt may further improve the outcomes of occlusive portal vein thrombosis in liver cirrhosis with variceal bleeding. However, the safety of transjugular intrahepatic portosystemic shunt remains uncertain in patients with occlusive portal vein thrombosis.

Study Design

Allocation: Randomized, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Portal Vein Thrombosis

Intervention

Transjugular intrahepatic portosystemic shunt, Non-selective beta blockers, Endoscopic therapy, Anticoagulation

Status

Not yet recruiting

Source

Fourth Military Medical University

Results (where available)

View Results

Links

Published on BioPortfolio: 2015-07-01T07:23:22-0400

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PubMed Articles [6404 Associated PubMed Articles listed on BioPortfolio]

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Medical and Biotech [MESH] Definitions

A type of surgical portasystemic shunt to reduce portal hypertension with associated complications of esophageal varices and ascites. It is performed percutaneously through the jugular vein and involves the creation of an intrahepatic shunt between the hepatic vein and portal vein. The channel is maintained by a metallic stent. The procedure can be performed in patients who have failed sclerotherapy and is an additional option to the surgical techniques of portocaval, mesocaval, and splenorenal shunts. It takes one to three hours to perform. (JAMA 1995;273(23):1824-30)

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