Esophageal Motility in Reflux Induced Cough

2015-07-09 08:38:23 | BioPortfolio


To determine whether contraction abnormalities in the esophagus plays a role in gastroesophageal reflux induced cough, and thus cough severity in patients with chronic cough.

Study Design

Observational Model: Case-Only, Time Perspective: Prospective




Citric Acid


Mayo Clinic in Florida
United States


Not yet recruiting


Mayo Clinic

Results (where available)

View Results


Published on BioPortfolio: 2015-07-09T08:38:23-0400

Clinical Trials [1352 Associated Clinical Trials listed on BioPortfolio]

Cough in Eastern and Central Finland

Comparison of citric acid and mannitol cough provocation tests among subjects with chronic cough and healthy volunteers.

Assessment of Voluntary and Reflex Cough in Patients With ALS

This study aims to assess the presence and the intensity of voluntary and cough reflex in patients with amyotrophic lateral sclerosis (ALS), comparing the results with the healthy control ...

A Study of the Effect of 20 mg Ambroxol Hydrochloride on Acute Cough.

To assess the effect of a single doses of 20 mg ambroxol hydrochloride on cough reflex sensitivity to citric acid, capsaicin, adenosine triphosphate (ATP) and distilled water in patients w...

A Cross-sectional Study to Measure Cough in Severe Asthma

This study aims to characterise cough in severe asthma through an observational cross-sectional analysis of patients stratified by inflammatory biomarker profile using a number of subjecti...

Effect of Gefapixant (MK-7264/AF-219) on Cough Reflex Sensitivity in Healthy and Chronic Cough Participants (MK-7264-014)

The primary objective of this study was to assess the effect of a single dose of gefapixant 100 mg on cough reflex sensitivity to various challenge agents (capsaicin, citric acid, adenosin...

PubMed Articles [6817 Associated PubMed Articles listed on BioPortfolio]

Quantifying test-retest variability of natural and suppressed citric acid cough thresholds and urge to cough ratings.

The citric acid cough reflex test (CRT) is used to quantify cough sensitivity and evaluate the effects of cough therapies and antitussive medications. This study quantifies the test-retest variability...

A systematic review of methods of citric acid cough reflex testing.

This systematic review summarises and appraises methods of citric acid cough reflex testing (CRT) documented in published literature.

An advanced recording and analysis system for the differentiation of guinea pig cough responses to citric acid and prostaglandin E2 in real time.

Cough number and/or sound have been used to assess cough sensitivity/intensity and to discriminate cough patterns in clinical settings. However, to date, only manual counting of cough number in an off...

Acetate-free bicarbonate dialysate: Which acid in the dialysis buffer?

The mix of bicarbonate and divalent cations requires a small amount of acid to avoid insoluble precipitation in the dialysate buffer. Small doses of acetic acid (3-7mmol/L) are commonly used. Acetic a...

Process for lanthanides-Y leaching from phosphogypsum fertilizers using weak acids.

Phosphogypsum (PG) precipitates as a by-product of the phosphoric acid industry when treating phosphate rocks with HSO. Lanthanides and trivalent yttrium content, Ln-Y, in the rock are mostly found in...

Medical and Biotech [MESH] Definitions

A key intermediate in metabolism. It is an acid compound found in citrus fruits. The salts of citric acid (citrates) can be used as anticoagulants due to their calcium chelating ability.

A dicarboxylic acid ketone that is an important metabolic intermediate of the CITRIC ACID CYCLE. It can be converted to ASPARTIC ACID by ASPARTATE TRANSAMINASE.

An enzyme that catalyzes the reversible hydration of fumaric acid to yield L-malic acid. It is one of the citric acid cycle enzymes. EC

Agents that suppress cough. They act centrally on the medullary cough center. EXPECTORANTS, also used in the treatment of cough, act locally.

A class of ketodicarboxylic acids derived from oxalic acid. Oxaloacetic acid is an intermediate in the citric acid cycle and is converted to ASPARTIC ACID by a transamination reaction.

More From BioPortfolio on "Esophageal Motility in Reflux Induced Cough"

Quick Search

Relevant Topic

Barrett's Esophagus
Barrett’s esophagus is a condition in which the tissue lining the esophagus—the muscular tube that carries food and liquids from the mouth to the stomach—is replaced by tissue that is similar to the intestinal lining. This process is ca...

Searches Linking to this Trial